Synthesis, characterization and crystal structures of copper(II), zinc(II) and vanadium(V) complexes, derived from 3-methyl-N′-(1-(pyridin-2-yl)ethylidene)benzohydrazide, with antibacterial activity

In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes

“…Vanadium compounds have been widely investigated due to a broad application in catalysis − and a wide range of pharmacological properties. − In the area of medicinal applications, the exploration of vanadium-based compounds has been focused on their insulin-mimetic properties, − ,− anticancer activities, − ,− antibacterial action, ,,,− and effects on enzymes. ,,, In particular, bis(ethylmaltolato)oxidovanadium(IV) (BEOV) entered the phase IIa clinical trials as an antidiabetic agent and its improved pharmacokinetics relative to vanadyl sulfate was evidenced. − Vanadocene dichloride, (η 5 -C 5 H 5 ) 2 VCl 2 (C 5 H 5 = cyclopentadienyl), was demonstrated to have antitumor effects on a wide spectrum of cancer cells, including testicular cancer, leukemia, breast cancer, glioblastoma, and colon cancer. − ,− Among oxidovanadium(IV) derivatives, special attention has been devoted to bis(4,7-dimethyl-1,10-phenanthroline)-sulfatooxidovanadium(IV) (Metvan), which was found to induce apoptosis in leukemia, multiple myeloma, and solid tumors such as breast, prostate, testis, and glioblasto...…”

Zinc(II) Complex Containing Oxazole Ring: Synthesis, Crystal Structure, Characterization, DFT Calculations, and Hirshfeld Surface Analysis

“…The free ligand 5-chloro-2-methylbenzoxazole shows high energy absorption bands at 280 and 287 nm, which are attributed to ligand π-π* transitions of the benzene ring and C=N bond respectively. 33,34 These absorption bands that remain unchanged in the spectrum of the complex indicate the coordination of the ligand to the Zn(II) metal center. Additionally, a new absorption peak in the complex was observed at 426 nm (23474 cm -1 ), which is attributed to the ligand-to-metal charge transfer (LMCT) that is characteristic of the zinc metal complex.…”

Crystal structure of bis(3-methoxy-N-(1-(pyridin-2-yl)ethylidene)benzohydrazonato κ3 O,N,N′)zinc(II), C30H28N6O4Zn

“…In the title structure, the asymmetric unit contains one half of the complex with Zn1 atom lying on the two fold rotational axis [see the figure, symmetry code: (i) −x + 1, −y + 1, z]. The C=O bonds of the hydrazone ligands are enolized, which could be confirmed by the C-O (C8-O1) bond lengths of 1.287(9) Å [4,5,7]. The central Zn(II) ion with a distorted octahedral coordination geometry is surrounded by two anionic ligands with N 2 O donor set.…”