Synthesis, characterization, and cytotoxic activity studies of new N₄O complexes derived from 2‐({3‐[2‐morpholinoethylamino]‐N3‐([pyridine‐2‐yl]methyl) propylimino} methyl)phenol

Abstract

A new unsymmetrical five-coordinate Schiff base ligand (HL) with an N 4 O donor set (2), has been prepared by condensation of N1-(2-morpholinoethyl)-N1-((pyridine-2-yl)methyl)propane-1,3-diamine with 2-hydroxy-benzaldehyde. Metal complexes [ML] n+ (

Evaluation of Anticancer Activity of Schiff bases Derived from Pyridine and their Metal Complexes- A Review

“…The cytotoxic effect of each compound against MCF-7, MDA-MB-231, PC-3, and WI-38 was examined using an MTT assay. All the complexes except 51h had higher potency towards MCF-7 and MDA-MB-231, and complex 51f had higher potency towards PC-3 (IC 50 =28.5±0.30) compared to Cisplatin 63 .…”

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

“…Recently, Rezaeivala et al 23 studied Cd (II) and Ag (II) complexes supported with 2‐({3‐[2‐morpholinoethylamino]‐ N 3‐[[pyridine‐2‐yl]methyl]propylimino}methyl)phenol have exhibited exceptional cytotoxic activity against breast cancer cells MCF‐7 and MDA‐MB‐231, nearly three times higher compared to cisplatin a well‐known used chemotherapeutic drug. Additionally, Tyagi et al 24 have demonstrated that Cu (II) and Co (II) complexes derived from 4‐amino‐5‐(pyridin‐4‐yl)‐4H‐1,2,4‐triazole‐3‐thiol exhibited significant activities against human breast cancer cell line (MCF‐7) and human hepatocellular liver carcinoma cell line (Hep‐G2).…”

“…Similarly, pyridine-and furfural-derived Schiff-base M (II) complexes have shown remarkable antioxidant, antimicrobial, and in vitro antitumor activity against human ovarian cancer cells, thus signifying the role of metal ion size, coordination environment, and redox potential in steering biological properties. 22 Recently, Rezaeivala et al 23 studied Cd (II) and Ag (II) complexes supported with 2-({3-[2-morpholinoethylamino]-N3-[[pyridine-2-yl]methyl]propylimino}methyl)ph enol have exhibited exceptional cytotoxic activity against breast cancer cells MCF-7 and MDA-MB-231, nearly three times higher compared to cisplatin a well-known used chemotherapeutic drug. Additionally, Tyagi et al 24 have demonstrated that Cu (II) and Co (II) complexes derived from 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol exhibited significant activities against human breast cancer cell line (MCF-7) and human hepatocellular liver carcinoma cell line (Hep-G2).…”