Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives

Abstract

Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by UV-Visible and FT-IR spectral data. Some of the new compounds were evaluated for their potential cytotoxicity against two different human cancer cell lines HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) in vitro, using Neutral Red and MTT assays. The synthesized compounds were active against two cell lines under study and a toxic effect was clear with a significant difference at the level of probability (p< 0.0001) and this effect was contrasted among different concentrations for each synthesized compound.

Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives

“…Encouraged by the fact that many pyrimidine-based compounds displayed broad spectrum biological activities such as anticancer, 19 anti-inflammatory, 20 and antibacterial, 21 we set out to assess the anticancer and anti-inflammatory activities and decipher the mode of action of eleven novel pyrimidine derivatives based on 4-trifluoromethylated 7-(substituted)-2H pyrimido[1,2-b] pyridazin-2-ones ( Fig. 1 ).…”