Synthesis, characterization and cytotoxic evaluation of inclusion complexes between Riparin A and β-cyclodextrin

Araújo, Éverton José Ferreira de; Silva, Oskar Almeida; Rezende-Júnior, Luís Mário; Sousa, Ian Jhemes Oliveira; Araújo, Danielle Ferreira Medeiro da Silva de; Carvalho, Rusbene Bruno Fonseca de; Pereira, Sergio Nunes; Gutierrez, Stanley Juan Chávez; Ferreira, Paulo Michel Pinheiro; Lima, Francisco das Chagas Alves

doi:10.1016/j.molstruc.2017.04.026

Cited by 12 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FT-IR study of drug, excipients and complexes were carried out with (FT-IR Alpha Bruker 1206 0280, Germany) by KBr disc method to identify the functional groups present in them. The spectra were recorded over the 4000-400 cm -1 range and analyzed [31,32].…”

Section: Ft-ir Analysismentioning

confidence: 99%

Development of Binary and Ternary Complex of Cefuroxime Axetil With Cyclodextrin for Improving Pharmaceutical Characteristics

Kaushik¹,

Verma²,

Purohit³

et al. 2020

Int J App Pharm

View full text Add to dashboard Cite

Objective: The current research objective is systematic development and characterization of binary and ternary inclusion complexes of cefuroxime axetil with β-cyclodextrin to improve its pharmaceutical characteristics by using the kneading method. Methods: Phase solubility study was carried out using Higuchi and Connors method. Based on its result, binary complexes of cefuroxime axetil with different ratio of β-cyclodextrin were developed and characterized using differential scanning calorimeter (DSC), fourier transform infrared spectroscopy (FT-IR) and X-ray powder diffractometry (XRD). Then, binary complexes were analyzed for in vitro dissolution testing. The ternary complexes were developed using different ratio of PVP K-30 as a ternary component and evaluated for in vitro dissolution testing and in vitro taste masking. Results: Binary complex of cefuroxime axetil with β-cyclodextrin (1:1) showed better drug release than pure drug. During the development of the ternary complex, β-cyclodextrin (1:1) and 1% w/v PVP K-30 as a ternary agent resulted in an optimized ternary complex. The DSC, FT-IR and XRD studies clearly revealed the formation of binary and ternary complexes. The ternary complex showed better drug release of>85% within 30 min. in comparison to binary complex. The in vitro taste-masking study revealed the taste masking efficiency of the ternary complex of cefuroxime with β-cyclodextrin. Conclusion: The developed binary and ternary complex of cefuroxime axetil based on β-cyclodextrin with PVP K-30 showed improved in vitro dissolution rate and taste masking in comparison to pure drug. The drug release was better in ternary complexes. The present research work successfully shows the utility of binary and ternary complexes for improving pharmaceutical characteristics of cefuroxime axetil.

show abstract

Section: Ft-ir Analysismentioning

confidence: 99%

Development of Binary and Ternary Complex of Cefuroxime Axetil With Cyclodextrin for Improving Pharmaceutical Characteristics

Kaushik¹,

Verma²,

Purohit³

et al. 2020

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Change in intensity and shifting of the peaks indicated the formation of new solid structure. [65,130,131] …”

Section: Xrd Analysismentioning

confidence: 99%

“…It showed that the evident between drug and polymer complexes presented higher concentrations of dissolved drug from the dissolutions of the samples and it reached the maximum dissolution. [131] Scanning electron microscopy (SEM):…”

Section: Dissolution Studiesmentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

View full text Add to dashboard Cite

Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

show abstract

“…Estimation of the Toxic Potential. The biopolymer's median lethal concentration (LC 50 ) was 239.4 mg•mL −1 (r 2 = 0 923), suggesting that the biopolymer has low toxic capacity [21,22].…”

Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 99%

Biopolymer from Adenanthera pavonina L. Seeds: Characterization, Photostability, Antioxidant Activity, and Biotoxicity Evaluation

Melo

Geronço

Sousa

et al. 2018

International Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

Plant polysaccharides have been increasingly employed in the pharmaceutical, industrial, and food environments due to their versatile functional properties. In the present investigation, a heteropolysaccharide galactomannan (GAP) was extracted from Adenanthera pavonina L. seeds and characterized by physicochemical analyses to determine its thermal properties, photostability, antioxidant activity, and acute toxicity. GAP was characterized by FTIR, DSC, and TG. The photostability of GAP submitted to artificial UV irradiation was analyzed. Antioxidant activity was evaluated by the DPPH (2,2-diphenyl-1-1-picrylhydrazyl) free radical-scavenging method, while a bioassay method was carried out to study acute toxicity in Artemia salina L. Physical-chemical and functional characteristics of GAP support its potential role in the food and pharmaceutical industries. GAP was photostable under UV irradiation. In vitro GAP antioxidant evaluation showed that it bears free radicalscavenging activity for DPPH radicals. The median lethal concentration (LC 50 ) of GAP was 239.4 mg•mL −1 , indicating that this biopolymer is nontoxic. Such results indicate that this biopolymer presents characteristics of neutrality, photostability, and nontoxicity that are commercially attractive.

show abstract

Synthesis, characterization and cytotoxic evaluation of inclusion complexes between Riparin A and β-cyclodextrin

Cited by 12 publications

References 35 publications

Development of Binary and Ternary Complex of Cefuroxime Axetil With Cyclodextrin for Improving Pharmaceutical Characteristics

Development of Binary and Ternary Complex of Cefuroxime Axetil With Cyclodextrin for Improving Pharmaceutical Characteristics

Untitled

Biopolymer from Adenanthera pavonina L. Seeds: Characterization, Photostability, Antioxidant Activity, and Biotoxicity Evaluation

Contact Info

Product

Resources

About