2011
DOI: 10.1016/j.jinorgbio.2011.03.009
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Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine

Abstract: a b s t r a c t a r t i c l e i n f o. When the condensation reaction is carried out in solution of nitriles (RCN, R = Me, Ph) the amidine derivatives cis-[(PPh 3 ) 2 PtNH=C(R){cyt(− 2H)}]NO 3 (R = Me, 5a; R = Ph, 5b) and cis-[(PPh 3 ) 2 PtNH= C(R){ado(− 2H)}]NO 3 (R = Me, 6a: R = Ph, 6b) are quantitatively formed. The coordination mode of these nucleosides, characterized in solution by multinuclear NMR spectroscopy and mass spectrometry, is similar to that previously observed for the nucleobases 1-methylcytos… Show more

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Cited by 17 publications
(5 citation statements)
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“…Apart from amines, other neutral ligands such as phosphanes have been exploited and one phosphane compound, the cisplatin analogue cis-Pt(PR 3 ) 2 Cl 2 (R = Me or Ph), has also been widely investigated in relation to its reactivity with nucleobases (Longato et al, 2006). In particular, the mixed phosphane/nucleobase complex cis-bis(triphenylphosphane)-[N-(1-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-4-ylidene)benzamidine]platinum(II) nitrate exhibits high antitumour activity (Montagner et al, 2011).…”
Section: Commentmentioning
confidence: 99%
“…Apart from amines, other neutral ligands such as phosphanes have been exploited and one phosphane compound, the cisplatin analogue cis-Pt(PR 3 ) 2 Cl 2 (R = Me or Ph), has also been widely investigated in relation to its reactivity with nucleobases (Longato et al, 2006). In particular, the mixed phosphane/nucleobase complex cis-bis(triphenylphosphane)-[N-(1-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-4-ylidene)benzamidine]platinum(II) nitrate exhibits high antitumour activity (Montagner et al, 2011).…”
Section: Commentmentioning
confidence: 99%
“…[19][20][21][22] known to inhibit the growth of several cancer lines [23][24][25][26] and many of them are clinically used as antiviral drugs. [30][31][32][33] In principle, a platinum complex conjugated to a biologically active nucleoside could combine the reactivity of the platinum center with the pharmacological properties of the nucleoside analogue (e.g., antimetabolite activity or active transmembrane transport). [30][31][32][33] In principle, a platinum complex conjugated to a biologically active nucleoside could combine the reactivity of the platinum center with the pharmacological properties of the nucleoside analogue (e.g., antimetabolite activity or active transmembrane transport).…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, various platinum(II) complexes of nucleotides, 12 nucleosides, 13,14,15 and nucleobase derivatives 16 have been reported as highly lethal to different kinds of cancers. Several platinum(II) compounds having adenosine 17,18 or an adenine derivative 19,20,21,22,23,24,25,26,27,28,29,30 as an ancillary ligand have also been reported to be highly cytotoxic toward various cancer cell lines. Although several platinum(IV) complexes with adenine derivatives as ligands have been reported, 31 we are unaware of any that have been tested as anticancer drugs.…”
Section: Introductionmentioning
confidence: 99%