Synthesis, characterization and DNA-Binding properties of the novel mononuclear Zn(II), Cd(II), and Mn(II) complexes with Pantoprazole

Abstract

A novel mononuclear Mn(II), Zn(II) and Cd(II) complexes of pantoprazole (PA) was synthesized and characterized by elemental analysis, molar conductivity, magnetic susceptibility measurements, IR, UV-visible spectral studies, and thermal analysis. The electronic spectra along with magnetic data suggest octahedral geometry for Mn(II), Zn(II) and Cd(II) complexes. PA acts as an anionic bi-dentate ligand being coordinated by (S=O) oxygen and benzimdazolyl nitrogen atoms. The interaction of the complexes with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed i n t r i n s i c b i n d i n g c o n s t a n t s together with structural analysis of the complexes indicate the groove binding. The binding constants were determined at 303°K, 308°K and 313°K. A thermodynamic analysis showed that the reaction is spontaneous with ΔG being negative. The enthalpy ΔH and the entropy ΔS of reactions were all determined.