Synthesis, characterization and drug release behavior of poly(1-vinyl 1,2,4-triazole) hydrogels prepared by gamma irradiation

Bayramgil, Nursel Pekel

doi:10.1016/j.colsurfb.2012.04.026

Cited by 20 publications

(15 citation statements)

References 31 publications

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“…. The glass transition temperatures for pure poly(AA) and poly(VTAz) were reported earlier as 124 and 171 °C, respectively , . As can be seen from Fig.…”

Section: Resultssupporting

confidence: 58%

Synthesis and characterization of poly[(1‐vinyl‐1,2,4‐triazole)‐co‐(monomer with carboxylic acid group(s))] and determination of monomer reactivity ratios: I. Acrylic acid

Kılıç

Bayramgil

2012

Polymer International

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Copolymers of 1‐vinyl‐1,2,4‐triazole (VTAz) and acrylic acid (AA) having different mole ratios were synthesized using free radical‐initiated solution polymerization in dimethylformamide at 70 °C with α,α′‐azobisisobutyronitrile as initiator in nitrogen atmosphere. The compositions of the synthesized copolymers for a wide range of monomer feeds were determined using Fourier transform infrared (FTIR) spectroscopy through recorded absorption bands for VTAz (1510 cm−1, CN (triazole ring) stretching mode) and AA (1710 cm−1, CO stretching mode) units. The structures of the copolymers were characterized using FTIR and 1H NMR spectroscopy. The copolymer compositions were also determined from 1H NMR analysis following proton signals of carboxyl group at 11.8–12.5 ppm of AA and of triazole ring at 7.5–8.1 ppm of VTAz. Monomer reactivity ratios for the VTAz‐AA pair were estimated using linear methods, i.e. Fineman–Ross (FR) and Kelen–Tüdös (KT). From FTIR evaluation, monomer reactivity ratios were calculated as r1 = 0.404 and r2 = 1.496 using the FR method and r1 = 0.418 and r2 = 1.559 using the KT method. These values were found to be very close to those obtained from NMR evaluation. The two cases r1r2 < 1 and r1 < r2 indicated the random distribution of the monomers in the final copolymers and the presence of a greater amount of AA units in the copolymer than in the feed, respectively. The observed relatively high activity of complexed growing radical‐AA• … VTAz was explained by the effect of complex formation between carbonyl groups and triazole fragments in chain growth reactions. Thermal behaviours of copolymers with various compositions were investigated using thermogravimetric and differential scanning calorimetric analyses. It was observed that thermal stabilities and glass transition temperatures of the copolymers increased resulting from complex formation between acid and triazole units. © 2012 Society of Chemical Industry

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“…. The glass transition temperatures for pure poly(AA) and poly(VTAz) were reported earlier as 124 and 171 °C, respectively , . As can be seen from Fig.…”

Section: Resultssupporting

confidence: 58%

Synthesis and characterization of poly[(1‐vinyl‐1,2,4‐triazole)‐co‐(monomer with carboxylic acid group(s))] and determination of monomer reactivity ratios: I. Acrylic acid

Kılıç

Bayramgil

2012

Polymer International

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“…They can be cast into practically any shape, size, or form [4] for different applications such as controlled drug release devices [5][6][7], tissue engineering scaffolds [8] and biosensors [9]. In recent years, stimuli-responsive polymers have been vigorously investigated due to their attractive properties: volume or phase transitions in response to slight environmental changes including temperature [10], pH [11], salt concentration [12] and magnetism [13].…”

Section: Introductionmentioning

confidence: 99%

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Wei

et al. 2015

Colloids and Surfaces B: Biointerfaces

118

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“…Figure S1 (Supporting Information) shows the ATR‐FTIR spectra of the PNAGA‐PVTZ copolymer hydrogels and PNAGA single component hydrogel. The three spectrograms show several identical characteristic peaks at 3071 cm −1 (NH), 2931 cm −1 (CH), and 1542 cm −1 (CO, CN, CN), A unique stretching vibration peak at 962 cm −1 was attributed to CH in the ring of PVTZ, suggesting the successful incorporation of PVTZ into the copolymer hydrogel. To further verify the formation of PNAGA‐PVTZ copolymer, 1 H NMR spectra were recorded (Figure S2, Supporting Information).…”

Section: Resultsmentioning

confidence: 97%

A High Strength Self-Healable Antibacterial and Anti-Inflammatory Supramolecular Polymer Hydrogel

Wang

Zhu

et al. 2017

Macromol. Rapid Commun.

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There is a significant cost to mitigate the infection and inflammation associated with the implantable medical devices. The development of effective antibacterial and anti-inflammatory biomaterials with novel mechanism of action has become an urgent task. In this study, a supramolecular polymer hydrogel is synthesized by the copolymerization of N-acryloyl glycinamide and 1-vinyl-1,2,4-triazole in the absence of any chemical crosslinker. The hydrogel network is crosslinked through the hydrogen bond interactions between dual amide motifs in the side chain of N-acryloyl glycinamide. The prepared hydrogels demonstrate excellent mechanical properties—high tensile strength (≈1.2 MPa), large stretchability (≈1300%), and outstanding compressive strength (≈11 MPa) at swelling equilibrium state. A simulation study elaborates the changes of hydrogen bond interactions when 1-vinyl-1,2,4-triazole is introduced into the gel network. It is demonstrated that the introduction of 1-vinyl-1,2,4-triazole endowes the supramolecular hydrogels with self-repairability, thermoplasticity, and reprocessability over a lower temperature range for 3D printing of different shapes and patterns under simplified thermomelting extrusion condition. In addition, these hydrogels exhibit antimicrobial and anti-inflammatory activities, and in vitro cytotoxicity assay and histological staining following in vivo implantation confirm the biocompatibility of the hydrogel. These hydrogels with integrated multifunctions hold promising potential as an injectable biomaterial for treating degenerated soft supporting tissues.

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Synthesis, characterization and drug release behavior of poly(1-vinyl 1,2,4-triazole) hydrogels prepared by gamma irradiation

Cited by 20 publications

References 31 publications

Synthesis and characterization of poly[(1‐vinyl‐1,2,4‐triazole)‐co‐(monomer with carboxylic acid group(s))] and determination of monomer reactivity ratios: I. Acrylic acid

Synthesis and characterization of poly[(1‐vinyl‐1,2,4‐triazole)‐co‐(monomer with carboxylic acid group(s))] and determination of monomer reactivity ratios: I. Acrylic acid

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

A High Strength Self-Healable Antibacterial and Anti-Inflammatory Supramolecular Polymer Hydrogel

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