Synthesis, characterization, and evaluation of antimicrobial activity of novel Chitosan/Tigecycline composite

Menazea, A.A.; Eid, May; Ahmed, M.K.

doi:10.1016/j.ijbiomac.2020.01.041

Cited by 98 publications

(14 citation statements)

References 41 publications

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“…Such antimicrobial polymers can be applied as packaging materials, wound-dressing materials, edible films and coatings and wrapping materials, as well as in tissue engineering and drug delivery. The antimicrobial activity of chitosan, its derivatives and composites against Gram-positive and Gram-negative bacteria has been demonstrated in many studies [ 79 , 80 , 81 , 82 ]. It was found that the outer barrier present in Gram-negative bacteria makes these species very susceptible to chitosan [ 83 , 84 , 85 ].…”

Section: Resultsmentioning

confidence: 99%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide–dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox® test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.

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Section: Resultsmentioning

confidence: 99%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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“…Therefore, chitosan is widely used in drug delivery due to its technological properties, which allow us to process the polymer in different ways (Table 5). [190,191] Nanocomposites [192,193] Composites [194] Initially, a chitosan salt (chitosan hydrochloride) was approved in 2002 by the Pharmacopeia. Chitosan was first introduced as an excipient into the European Pharmacopeia 6.0 and the 29th edition of the United States Pharmacopeia (USP) 34-NF almost ten years later.…”

Section: Chitosan In Drug Deliverymentioning

confidence: 99%

Chitosan: An Overview of Its Properties and Applications

et al. 2021

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Chitosan has garnered much interest due to its properties and possible applications. Every year the number of publications and patents based on this polymer increase. Chitosan exhibits poor solubility in neutral and basic media, limiting its use in such conditions. Another serious obstacle is directly related to its natural origin. Chitosan is not a single polymer with a defined structure but a family of molecules with differences in their composition, size, and monomer distribution. These properties have a fundamental effect on the biological and technological performance of the polymer. Moreover, some of the biological properties claimed are discrete. In this review, we discuss how chitosan chemistry can solve the problems related to its poor solubility and can boost the polymer properties. We focus on some of the main biological properties of chitosan and the relationship with the physicochemical properties of the polymer. Then, we review two polymer applications related to green processes: the use of chitosan in the green synthesis of metallic nanoparticles and its use as support for biocatalysts. Finally, we briefly describe how making use of the technological properties of chitosan makes it possible to develop a variety of systems for drug delivery.

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“…Effect of contact time on the rate of adsorption using Egyptian date pits were performed at natural pH, 25 °C temperature and adsorbent dose of 0.1 g/50 mL solution and automatically shaken for the selected period of time (5,10,15,20,30,40, 50 min).…”

Section: Effect Of Contact Timementioning

confidence: 99%

“…The amount of adsorbed dye on Egyptian date pits was calculated using this equation: The adsorption isotherm indicates how the adsorbed molecules are distributed between the solid and liquid phases at equilibrium [15]. Finding a suitable model to describe the adsorption process is an important step and it is done by analyzing of the equilibrium data where these data is fitted with different isotherm models.…”

Section: Equilibrium Isothermsmentioning

confidence: 99%

Untitled

Mohamed

2021

Asian J. Nanosci. Mater.

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This study aimed to investigate Egyptian date pits' potential to remove a cationic dye, specifically methylene blue (MB), from aqueous solutions. Characteristics of methylene blue and interaction between methylene blue and Egyptian date pits were characterized using the Fourier transform infrared spectrometer, scanning electron microscope, and Brunauer-Emmett-Teller analysis. The effect of several parameters including, adsorbent dose, and contact time, temperature and pH solution were assessed. The adsorption was increased by decreasing dye concentration, temperature, increasing contact time and dosage up to equilibrium values which was 25 °C, 20 min, and 0.1 g adsorbent, respectively. At high pH, the adsorption was promising. The results demonstrated that the Egyptian date pits are an effective and good adsorbent for removing Methylene blue in wastewater.

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Synthesis, characterization, and evaluation of antimicrobial activity of novel Chitosan/Tigecycline composite

Cited by 98 publications

References 41 publications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Chitosan: An Overview of Its Properties and Applications

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