Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

Abstract

A Schiff base ligand, 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one (BZHQO), has been synthesized by the condensation of 3‐hydrazinylquinoxalin‐2(1H)‐one and 1‐(1H‐benzoimidazol‐2‐yl) ethanone and characterized using spectral and single‐crystal X‐ray analyses. Mn (II), Co (II), Ni (II) and Cu (II) complexes of the BZHQO ligand have been synthesized and characterized. The interactions of the ligand and its metal complexes with calf thymus DNA have been investigated using absorption spectroscopy and the intrinsic binding constant has been evaluated. Agarose gel electrophoresis has been performed to study the abilities of the ligand and its metal complexes to cleave supercoiled pBR322 DNA into nicked circular form. In vitro anticancer activities of the Cu (II) and Ni (II) complexes have been investigated by MTT assay, using the cell lines HeLa, B16‐F10, SKOV3 and MCF7. The Cu (II) complex has been found to be active against HeLa, B16‐F10 and MCF7, while the Ni (II) complex has been found to be active against MCF‐7.

A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells

“…Therefore, complex 1 was selected for further studies. Additionally, when compared to other Cu II complexes containing analogous ligands, complex 1 has already been shown to stand out as one of the most active copper-based compounds 25 , 26 with high selectivity 22 , as it can be confirmed by the present work.…”

Retracted: A new Co(II)‐coordination polymer: Photocatalytic studies and treatment values on mania by reducing the ErbB4 expression on the noradrenergic neurons

“…[15] Since the first reported studies on the biological activity of cobalt complexes in 1952, many cobalt complexes of biological interest have been reported, with the most structurally characterized showing antitumor, antiproliferative, antimicrobial, and antifungal activity. [16][17][18][19][20] In our experiment, a novel CP based on Co(II) has been generated in the existence of a second N-donor ligand 3,3 0 -bipyridine (3,3 0 -bpy) utilizing 4,4 0 ,4 00 -phosphanetriyltribenzoic acid (H 3 tpp) as the tritopic connector under conditions of solvothermal reaction, and its chemical formula is [Co 3 (tpp) 2 (3,3 0 -bpy)]Á 7DMF (1). The product acquired was completely investigated using powder X-ray diffraction (PXRD), thermogravimetric analyses, infrared radiation (IR) spectra, and elemental analysis (EA), as well as the diffraction of a single-crystal X-ray.…”

Heterometallic coordination polymers: Treatment activity on diabetic foot by reducing the excess inflammatory response in the plantar tissue

“…Metal complexes, particularly those containing sp 2 hybrid nitrogens as part of the aromatic system of the ligands, find significant applications as drugs. 16 Besides, CPs can interact with DNA through noncovalent interactions, including intercalation and groove binding for large molecules and serve as external electrostatic binding sites for cations. 17 On the other hand, cobalt is an essential human element at the active site of vitamin B12, which indirectly regulates the synthesis of DNA, and has attracted many biological and organometallic chemists who have investigated cobalt complexes with the aim of…”