Synthesis, characterization and in vitro pharmacology of novel pregabalin derivatives

Horvat, Štefica; Hameršak, Zdenko; Stipetić, Irena; Jolas, Thierry

doi:10.1016/j.ejmech.2009.12.049

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…68 Glutaric anhydride 7 was desymmetrised using cinnamyl alcohol as developed in their previous report on pregablin synthesis (Scheme 28b). 68 Glutaric anhydride 7 was desymmetrised using cinnamyl alcohol as developed in their previous report on pregablin synthesis (Scheme 28b).…”

Section: Anhydride Desymmetrisation In Synthesismentioning

confidence: 99%

Organocatalytic enantioselective desymmetrisation

et al. 2016

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Organocatalytic enantioselective desymmetrisation of achiral or meso compounds is a powerful strategy for the construction of enantiomerically enriched complex molecules, often with multiple stereocentres and in high selectivities. Recent years have seen increasing use of organocatalysts in desymmetrisation methodology, in contrast to traditional metal- or enzyme-catalysed reactions, with many impressive advances made in the current decade. This review will provide an overview of the field since 2010, with the aim of highlighting both the practical applications and elegance of enantioselective desymmetrisation to the wider synthetic community.

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Section: Anhydride Desymmetrisation In Synthesismentioning

confidence: 99%

Organocatalytic enantioselective desymmetrisation

et al. 2016

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Organocatalytic Asymmetric Additions to meso‐Anhydrides and Azlactones

Rodríguez-Docampo

Connon

2011

ChemCatChem

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This review charts the recent progress of two related, yet distinct organocatalytic processes: the desymmetrisation of meso‐anhydrides and the dynamic kinetic resolution of azlactones. Driven by recent advances in catalyst design, both these processes have undergone something of a renaissance in recent years and are now becoming very powerful and versatile synthetic methodologies. The material is presented in a critical fashion and the material is organised by reaction type and catalyst class.

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