Synthesis, characterization and in vitro anticancer activity of 18-membered octaazamacrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II)

Kareem, Abdul; Zafar, Hina; Sherwani, Asif; Owais, Mohammad; Khan, Tabreiz Ahmad

doi:10.1016/j.molstruc.2014.06.073

Cited by 28 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last 30 years, the repertoire of compounds containing transition metals with anti-tumor properties has expanded to include compounds containing Zn, Co, Ni, Sn, Ag, and Cd. [43][44][45][46][47][48][49] Among these elements, cadmium has been ascribed elevated anti-tumor effects in comparison with other transition metals. 43 In 2016, Sreekanth et al reported that cadmium oxide (CdO) NPs inhibited the proliferation of normal and tumor cell lines, whereby the tumor cells were more severely affected by CdO NPs.…”

Section: In Vivo Metastasis Assaysmentioning

confidence: 99%

“…[43][44][45][46][47][48][49] Among these elements, cadmium has been ascribed elevated anti-tumor effects in comparison with other transition metals. 43 In 2016, Sreekanth et al reported that cadmium oxide (CdO) NPs inhibited the proliferation of normal and tumor cell lines, whereby the tumor cells were more severely affected by CdO NPs. 44 Our study shows that QDs-GSH have potent anti-tumor effects, as evidenced by the dramatic inhibition of cell proliferation and invasion following internalization of QDs-GSH.…”

Section: In Vivo Metastasis Assaysmentioning

confidence: 99%

See 1 more Smart Citation

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Díaz-García¹,

Guerrero²,

Díaz-Valdivia³

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundNumerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in biological systems and little is known about whether QDs affect the capacity of cancer cells to metastasize. Previously, we described the “biomimetic” synthesis of CdTe-QDs (QDs-glutathione [GSH]) with increased biocompatibility and the potential utility in labeling cells.PurposeIn order to determine the feasibility of using QDs-GSH as a tool for tracking tumor cells during early metastasis, we characterized here for the first time, the in vitro and in vivo effects of the incorporation of green or red biomimetic QDs-GSH into B16F10 cells, a syngeneic mouse melanoma line for metastasis assays in C57BL/6 mice.MethodsB16F10 cells were labeled with green or red biomimetic QDs-GSH in the presence or absence of n-acetylcysteine. Then, migration, invasion and proliferation of labeled B16F10 were evaluated in vitro. Finally, the B16F10 cells labeled with red QDs-GSH were used to monitor in vivo lung metastasis at early time points (5 minutes to 24 hours) or after 21 days in C57BL/6 mice.ResultsWe developed a methodology that allows obtaining QDs-GSH-labeled B16F10 cells (nearly 100% viable labeled cells), which remained viable for at least 5 days and migrated similarly to control cells. However, proliferation, invasion, and the capacity to form metastatic nodules in the lungs were severely attenuated. Fluorescence imaging revealed that distribution/accumulation of QDs-GSH-labeled B16F10 cells could be tracked following injection into C57BL/6 mice (syngeneic preclinical metastasis model) and that these cells preferentially accumulated in the perialveolar area in lungs as early as 5 minutes post-injection.ConclusionThe methodology described here represents a useful alternative for monitoring initial events during tumor cell metastasis.

show abstract

Section: In Vivo Metastasis Assaysmentioning

confidence: 99%

Section: In Vivo Metastasis Assaysmentioning

confidence: 99%

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Díaz-García¹,

Guerrero²,

Díaz-Valdivia³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…An octahedral cobalt (II) ion in a high-spin state may have contributed to the orbital contribution of the reported magnetic moment, which is larger (4.02 BM). In the copper (II) complex scenario (Table 5.3), a broad and strong region conducive to 2 Eg→ 2 T2g Cu(II) ion transition in a distorted octahedral structure was observed [25]. The observed values of the magnetic moment (1.73 BM) of the copper (II) complex are consistent with an orbitally non-degenerate ground state [26].…”

Section: Electronic Spectra and Magnetic Moment Datamentioning

confidence: 74%

Synthesis, Structural Characterization Of Benzothiazole Schiff Base Metal (II) Complexes And Their Interaction With DNA

Pratiba¹,

Betageri²,

Latha³

et al. 2022

Journal of Pharmaceutical Negative Results

View full text Add to dashboard Cite

A potential metal-based chemotherapeutic product based on a benzothiazole Schiff base and first-row transition metals was synthesizedand illustrated analytically and spectrally to investigate the biochemical priority of transition-metal drugs for molecular target DNA.As a result of the magnetic susceptibility data, it was shown that Co (II), Ni (II) and Cu (II) complexes are paramagnetic and have anoctahedral geometry at ambient temperatures. Molar conductivity experiments showed that almost all of the complexes in dimethylformamide were non-electrolytes. This study examined the interactions between CT-DNA and metal (II) complexes. Therefore, thecopper(II) complex significantly improves DNA binding compared to the other complexes. Additionally, this finding was supported bygel electrophoresis, thermal denaturation, and viscosity methods.

show abstract

“…It seems that ligand type used for preparation of Cd complexes may cause their very favorable anti-tumor effects [17]. Ligands used for preparation of Cd complexes can be classified as: thiosemicarbazones [16,[18][19][20][21][22][23][24], selenosemicarbazones [25][26][27], hydrazones [16,[27][28][29][30][31][32][33][34][35][36], hydrazides [38,39], diimines [40], amides [41,42], aminoacids [43,44], heterocycles [44][45][46][47][48][49][50][51][52][53][54][55][56], macrocycles [58][59][60], drugs [61][62][63]…”

Section: Introductionmentioning

confidence: 99%

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells

Bjelogrlić

Todorović

Cvijetić

et al. 2019

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies. Compared to 1, cisplatin (CDDP) does not achieve cell death in 2D cultured AsPC-1 cells, while induces different pattern of cell cycle changes and caspase activation in 2D cultured MCF-7 cells, implying that these two compounds do not share similar mechanism of action. Additionally, 1 acts as a powerful inducer of mitochondrial superoxide production with dissipated trans-membrane potential in the majority of the treated cells already after 6 h of incubation. On 3D tumors, 1 displays a superior activity against CSC model, and at 100 μM induces disintegration of spheroids within 2 days of incubation. Fluorescence spectroscopy, along with molecular docking show that compound 1 binds to the minor groove of DNA. Compound 1 binds to the human serum albumin (HSA) showing that the HSA can effectively transport and store 1 in the human body. Thus, our current study strongly supports further investigations on antitumor activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer.

show abstract

Synthesis, characterization and in vitro anticancer activity of 18-membered octaazamacrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II)

Cited by 28 publications

References 36 publications

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging

Synthesis, Structural Characterization Of Benzothiazole Schiff Base Metal (II) Complexes And Their Interaction With DNA

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells

Contact Info

Product

Resources

About