Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG/gelatin nanocomposites

Raj, V.; Prabha, G.

doi:10.1016/j.jaubas.2015.08.001

Cited by 33 publications

(24 citation statements)

References 40 publications

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“…Raj et al investigated the possibility of utilizing cisplatin-loaded cassava starch acetate-polyethylene glycol (PEG)-gelatin nanocomposite for anticancer drug delivery [129]. The nanocomposite drug release system was based on pH and time.…”

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

Protein–Polysaccharide Composite Materials: Fabrication and Applications

et al. 2020

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Protein–polysaccharide composites have been known to show a wide range of applications in biomedical and green chemical fields. These composites have been fabricated into a variety of forms, such as films, fibers, particles, and gels, dependent upon their specific applications. Post treatments of these composites, such as enhancing chemical and physical changes, have been shown to favorably alter their structure and properties, allowing for specificity of medical treatments. Protein–polysaccharide composite materials introduce many opportunities to improve biological functions and contemporary technological functions. Current applications involving the replication of artificial tissues in tissue regeneration, wound therapy, effective drug delivery systems, and food colloids have benefited from protein–polysaccharide composite materials. Although there is limited research on the development of protein–polysaccharide composites, studies have proven their effectiveness and advantages amongst multiple fields. This review aims to provide insight on the elements of protein–polysaccharide complexes, how they are formed, and how they can be applied in modern material science and engineering.

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Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

Protein–Polysaccharide Composite Materials: Fabrication and Applications

et al. 2020

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“…The most important issue is the parameter k 2[S] that may be seen as the rate limiting factor. This factor should be seen to be important in the clearance of starch or modified starch from starch or modified starch based encapsulating agents [41][42][43] for therapeutic drug delivery to target tissue and organ. Although k 2 may appear to be sufficient in monitoring the rate of production of reducing sugar, but the means to an end could be more important.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2017

JAPLR

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Background: There has been an equation which unifies all common kinetic parameters to the exclusion of pseudo-first order rate constant. Much attention had been paid to rate constant for the production of reducing sugars during amylolysis catalyzed by alpha amylase. There seems not be concern for the rate (k 2[S] ) of amylolysis of glycosidic bond and making of bonds. Modification of active site for therapeutic and scientific reasons can alter the value of k 2[S] .Objectives: The objectives of this research are the formulation of an additional, simple, and verifiable mathematical models that can be used to determine the parameter, exp Method:The theoretical aspect entailed the derivation of different equations while the experimental aspect entailed the application of Bernfeld method of enzyme assay; this was used to determine the molar concentration of reducing sugar produced. ~1/2 nd of k 2 ; this shows that hydrolysis of glycosidic bond and making of new bonds is the rate limiting step. Estimation of the duration of assay needed to produce a desired amount of reducing sugar may be for feature investigation. Results: Unpaired t -test showed that

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“…Cisplatin is used to treat tumors in various parts of the body such as the head, neck, respiratory, digestive, and renal systems [ 127 , 128 ]. The clinical application of CDDP for cancer chemotherapy is still in limited because of its nonspecific bio-distribution and severe side effects [ 129 ]. Raj studied encapsulation of the anticancer drug CDDP into cassava starch acetate/polyethylene glycol/gelatin (CSA/PEG/G) nanocomposites through the interaction between CDDP and CSA/PEG/G nanocomposites.…”

Section: Drug Delivery From Nanocompositesmentioning

confidence: 99%

Bioactive Nanocomposites for Tissue Repair and Regeneration: A Review

Bramhill

Ross

2017

IJERPH

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This review presents scientific findings concerning the use of bioactive nanocomposites in the field of tissue repair and regeneration. Bioactivity is the ability of a material to incite a specific biological reaction, usually at the boundary of the material. Nanocomposites have been shown to be ideal bioactive materials due the many biological interfaces and structures operating at the nanoscale. This has resulted in many researchers investigating nanocomposites for use in bioapplications. Nanocomposites encompass a number of different structures, incorporating organic-inorganic, inorganic-inorganic and bioinorganic nanomaterials and based upon ceramic, metallic or polymeric materials. This enables a wide range of properties to be incorporated into nanocomposite materials, such as magnetic properties, MR imaging contrast or drug delivery, and even a combination of these properties. Much of the classical research was focused on bone regeneration, however, recent advances have enabled further use in soft tissue body sites too. Despite recent technological advances, more research is needed to further understand the long-term biocompatibility impact of the use of nanoparticles within the human body.

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Synthesis, characterization and in vitro drug release of cisplatin loaded Cassava starch acetate–PEG/gelatin nanocomposites

Cited by 33 publications

References 40 publications

Protein–Polysaccharide Composite Materials: Fabrication and Applications

Protein–Polysaccharide Composite Materials: Fabrication and Applications

Untitled

Bioactive Nanocomposites for Tissue Repair and Regeneration: A Review

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