Synthesis, Characterization and In Vitro Antibacterial Evaluation of Novel 4-(1-(Pyrimidin-4-yl)Ethyl)-12<i>H</i>-Pyrimido[4′,5′:5,6][1,4]Thiazino[2,3-<i>b</i>]Quinoxaline Derivatives

Afrough, Toktam; Bakavoli, Mehdi; Beyzaei, Hamid; Moghaddam‐Manesh, Mohammadreza

doi:10.1080/10406638.2019.1614640

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…A series of seven compounds were synthesized and characterized which were then subjected to in vitro antibacterial activity against a panel of 11 Gram‐positive and 10 Gram‐negative bacteria. Results were demonstrated as inhibition zone diameter, MIC and MBC wherein compounds 112 a and 112 b were the most potent compounds having significant activities against nine and six bacteria, respectively with MIC values ranging between 51–204 μg/mL as compared to standards, ceftriaxone, penicillin, cefazolin [62] …”

Section: Pharmacological Activities Of Quinoxaline‐based Compoundsmentioning

confidence: 99%

“…Results were demonstrated as inhibition zone diameter, MIC and MBC wherein compounds 112 a and 112 b were the most potent compounds having significant activities against nine and six bacteria, respectively with MIC values ranging between 51-204 μg/mL as compared to standards, ceftriaxone, penicillin, cefazolin. [62] A series of quinoxaline derivatives were designed and synthesized by Dewangan et al as antimicrobial agents (113, Figure 32). All the synthesized compounds were assayed for in vitro antibacterial activity against the gram-positive bacteria [S. aureus (MTCC 96) and S. pyogenes (MTCC 442)] and gramnegative bacteria [E. coli (MTCC 443) and P. aeruginosa (MTCC 424)].…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

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A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

2023

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In last few decades, nitrogen‐containing heterocycles have maintained their status as an important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is one such class of nitrogen‐containing scaffold that has become a subject of extensive research as it possess a plethora of biological activities. Molecular hybridization is a versatile and rational approach to drug design that involves the combination of two bioactive molecules possessing distinct intrinsic activity into a single scaffold for enhancing their therapeutic potential. In view of this, the advancement and potential of quinoxaline hybrids bearing thiazole, triazole, oxadiazole, pyrrolizines, pyrazole, etc. have attracted the keen attention of researchers to explore their therapeutic ability against different biological targets. The present review includes the research in the recent years (2018–2023) and addresses the graceful advancements in the studies related to quinoxaline‐based small molecules including their synthetic routes, biological activities and structure‐activity relationships. We anticipate that this review article will provide comprehensive knowledge of pharmacological importance of quinoxaline analogues and will fulfill the need of scientific community in designing and developing efficacious novel molecules.

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Section: Pharmacological Activities Of Quinoxaline‐based Compoundsmentioning

confidence: 99%

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

2023

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“…tidepressant [23], anthelmintic [24], analgesic [25][26][27][28][29][30][31], anti-inflammatory [11,[32][33][34][35][36], antiviral [37][38][39][40][41][42][43], antifungal [44][45][46][47][48][49], antimalarial [50][51][52][53][54][55], antibacterial [56][57][58][59][60][61][62][63], antioxidant [14,[64][65], antithrombotic [66,67] and antiprotozoal [54,68]. Different quinoxaline-based drugs have been playing a main role in the therapy and treatment of various diseases, such as varenicline 4 (aids in smoking cessation), brimonidine 5 (an...…”

Section: Introductionmentioning

confidence: 99%

Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

et al. 2021

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Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of pharmacological activities. Therefore, the therapeutic potential and biomedical applications of quinoxalines have been enhanced by incorporation of the sulfonamide group into their chemical framework. The present review surveyed the literature on the preparation, biological activities and structure-activity relationship (SAR) of quinoxaline sulfonamide derivatives due to their broad range of biomedical activities, such as diuretic, antibacterial, antifungal, neuropharmacological, antileishmanial, anti-inflammatory, anti-tumor and anticancer action. The current biological diagnostic findings in this literature review suggest that quinoxaline-linked sulfonamide hybrids are capable of being established as lead compounds; modifications on quinoxaline sulfonamide derivatives may give rise to advanced therapeutic agents against a wide variety of diseases.

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Synthesis of novel Fe3O4 nanostructures surrounded by Ti-MOF nanostructures as bioactive and efficient catalysts in three-component synthesis of new pyrazole derivatives

Saeed

Waleed²,

Alkaaby³

et al. 2023

Front. Mater.

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Synthesis and reporting of new nanoparticles with diverse properties is important in chemistry. A one-step, rapid and controllable synthesis of the new Fe3O4 surrounded in Ti-MOF nanostructures was carried out with microwave technology. After identifying and confirming the structure, Fe3O4 surrounded in Ti-MOF nanostructures was used as a suitable catalyst with high thermal resistance and recyclable in a three-component reaction of phenylhydrazine, malononitrile and aldehyde to synthesis novel pyrazole derivatives. Continuing investigations on Fe3O4 surrounded in Ti-MOF nanostructures, its antimicrobial properties were tested on Gram-positive bacterial species, Gram-negative bacterial species and fungi bacterial. Identification of Fe3O4 surrounded in Ti-MOF nanostructures with morphology and size distribution technique (SEM), surface area technique (BET), Infrared spectroscopy (FT-IR), Energy-Dispersive X-ray spectroscopy (EDX/EDX mapping), and Vibrating Sample Magnetometer (VSM) were performed. Synthesized pyrazole derivatives with Fe3O4 surrounded in Ti-MOF nanostructures than previously reported methods have less synthesis time and high efficiency. In antimicrobial properties high effects were observed based on MIC, MBC, and MFC values.

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Synthesis, Characterization and In Vitro Antibacterial Evaluation of Novel 4-(1-(Pyrimidin-4-yl)Ethyl)-12H-Pyrimido[4′,5′:5,6][1,4]Thiazino[2,3-b]Quinoxaline Derivatives

Cited by 3 publications

References 28 publications

A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

Synthesis of novel Fe3O4 nanostructures surrounded by Ti-MOF nanostructures as bioactive and efficient catalysts in three-component synthesis of new pyrazole derivatives

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