Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

Rahdar, Abbas; Hajinezhad, Mohammad Reza; Sivasankarapillai, Vishnu Sankar; Askari, Faezeh; Noura, Mehdi; Kyzas, George Z.

doi:10.1007/s00339-020-03535-0

Cited by 16 publications

(9 citation statements)

References 62 publications

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“…In vivo toxicity of nanomaterials is another point of concern deserving careful investigation. In recent years, metal oxide NPs have been synthesized for medical engineering purposes, such as magnetite NPs, zinc oxide NPs, and cerium oxide NPs [ 20 , 21 , 22 ]. Despite the wide range of metal oxide NPs, there is a relative paucity of data about the potential side effects of these nanomaterials.…”

Section: Discussionmentioning

confidence: 99%

Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity

et al. 2021

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In this research, tin ferrite (SnFe2O4) NPs were synthesized via hydrothermal route using ferric chloride and tin chloride as precursors and were then characterized in terms of morphology and structure using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), X-ray power diffraction (XRD), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) method. The obtained UV-Vis spectra was used to measure band gap energy of as-prepared SnFe2O4 NPs. XRD confirmed the spinel structure of NPs, while SEM and TEM analyses disclosed the size of NPs in the range of 15–50 nm and revealed the spherical shape of NPs. Moreover, energy dispersive X-ray spectroscopy (EDS) and BET analysis was carried out to estimate elemental composition and specific surface area, respectively. In vitro cytotoxicity of the synthesized NPs were studied on normal (HUVEC, HEK293) and cancerous (A549) human cell lines. HUVEC cells were resistant to SnFe2O4 NPs; while a significant decrease in the viability of HEK293 cells was observed when treated with higher concentrations of SnFe2O4 NPs. Furthermore, SnFe2O4 NPs induced dramatic cytotoxicity against A549 cells. For in vivo study, rats received SnFe2O4 NPs at dosages of 0, 0.1, 1, and 10 mg/kg. The 10 mg/kg dose increased serum blood urea nitrogen and creatinine compared to the controls (P < 0.05). The pathology showed necrosis in the liver, heart, and lungs, and the greatest damages were related to the kidneys. Overall, the in vivo and in vitro experiments showed that SnFe2O4 NPs at high doses had toxic effects on lung, liver and kidney cells without inducing toxicity to HUVECs. Further studies are warranted to fully elucidate the side effects of SnFe2O4 NPs for their application in theranostics.

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Section: Discussionmentioning

confidence: 99%

Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity

et al. 2021

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“…Nanoparticles are microscopic particles with a diameter of 1 to 100 nanometers that are used in current textile technology. Nanoparticles also have a wide range of applications in life science [1,2], biomedical [3,4], healthcare [4], and security [5] as well as the energy generation [6], farming [7], sustainable energy [6,7], energy storage [6,8], infrastructure [9], and building and constructions [10]. Because of their capacity to transfer charges and give fast responses, as well as their ease of use and inexpensive cost, ZnO NPs are a popular choice among nanoparticles for a range of applications.…”

Section: Introductionmentioning

confidence: 99%

“…At this time, the ozone layer has completely absorbed UV-C. From all UV radiation, the most damaging types of radiation are UV-A and UV-B. It has high energy and a short wavelength [4][5][6]15]. In order to reduce such effects, ZnO NPs must be synthesized for textiles industries.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Zinc Oxide Nanoparticles by Hydrothermal Methods and Spectroscopic Investigation of Ultraviolet Radiation Protective Properties

Bekele¹,

Jule²,

Degefa³

et al. 2021

Journal of Nanomaterials

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Ultraviolet radiation causes damages to the human body, such as skin ageing, skin cancer, and allergies throughout the world. Applying zinc oxide nanoparticles (ZnO NPs) in sunscreen products (like cloths or textiles) to protect human skin by absorbing the ultraviolet radiations that emerged from the sun. The main aim of this study is to investigate both absorbance and transmittance characteristics of the untreated and treated cotton textiles. For ZnO NPs using hydrothermal methods, they were made from Zn(NO3)2·6H2O and NaOH at a constant annealing temperature of 300°C. Fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-vis spectroscopy were used to analyze the produced ZnO NPs. From the FT-IR result, ZnO NPs were observed in the region of 400-600 cm-1. Wurtzite hexagonal structure of ZnO NPs with the average crystal size 32 ± 49 nm was observed from XRD results. Flowers in the shape of synthesized ZnO NPs were observed from SEM images. The UV-vis penetration peaks were identified at 264 nm and 376 nm, with energy band gaps of 4.68 and 3.536 eV, respectively. When compared to bulk ZnO, the energy band gap of ZnO NPs was blue-shifted due to the impact of quantum confinement. The peaks in UV-vis absorption were caused by an electronic transition from the valiancy to the conduction bands. The high energy band shows high absorbance of the synthesis sample in the case of 264 nm. The ZnO NPs were manufactured and applied to 100% of raw cotton to impart sunscreen action to both untreated and treated cotton fabrics. The performance of treatment has been evaluated utilizing UV-vis spectroscopy through quantifying ultraviolet protective factors (UPF) and percentage of transmitted (%T) radiations. The treated cotton textiles have 61.50% UPF while 2.65% ultraviolet radiations were transmitted. In other words, untreated cotton textiles have 1.63% UPF while 74.56% ultraviolet radiation was transmitted. Therefore, the treated cotton textiles have excellent protection categories when compared to untreated cotton textiles.

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“…With this in mind, as a continuous effort related to the synthesis of nanomaterials and investigation of their potential in biological applications [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ], we currently review here different nanomaterials applied to diagnosis and treatment of inflammatory arthritis.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus

Cited by 16 publications

References 62 publications

Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity

Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity

Synthesis of Zinc Oxide Nanoparticles by Hydrothermal Methods and Spectroscopic Investigation of Ultraviolet Radiation Protective Properties

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

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