Synthesis, Characterization and Microbial Activity of Chiral Mixed Ligand Transition Metal Complexes

Shivankar, Vitthal S.; Gaikwad, Y. A.; Mulla, H. U.; Gavali, Laxman

doi:10.9790/5736-0212633

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Metal complexes containing two or more different metal ions are always of interest in different field like multimetallic enzymes 1 and catalysis 2,3 . A large number of Schiff bases and their complexes have been studied for its interesting and important properties such as catalytic activity 4 and transfer of the amino group, photochromic properties and complexing ability towards some toxic metals 5 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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From the analytical data; it was observed that all the complexes exhibited 1:1 (methyl: ligand) ratio. IR data shows that the ligand co-ordinates with metal ions in a bidentate manner through the two oxygen atoms. Thermal analysis shows the degradation pattern of the complexes. The synthesized metal complexes were then tested in vitro for biological activities against Bacillus subtilis, Staphylococcus Aureus, and Escherichia coli to assess their antibacterial and antifungal effect. Some of them showed promising antimicrobial activity.

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Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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“…Ternary complexes containing an amino acid as a secondary ligand are of significance as they are potential models for enzymemetal ion substrate complexes [6]. It has been found that a majority of the metal complexes with 8-hydroxyquinoline possessing biological activities [7].…”

Section: Introductionmentioning

confidence: 99%

Mixed Ligand Co (II) Complexes: Use as Catalysts in the Hydrolysis of Esters

Shivankar¹

2013

IOSR-JAC

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The Importance of Heterolepticity in Improving the Antibacterial Activity of Bismuth(III) Thiolates

et al. 2016

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Five mixed thiolatobismuth(III) complexes [BiPh(5‐MMTD)2{4‐MMT(H)}] (1), [Bi(1‐MMTZ)2{(PYM)(PYM(H))2}] (2), [Bi(MBT)2(5‐MMTD)] (3), [Bi(4‐BrMTD)3{2‐MMI(H)}] (4) and [Bi(1‐MMTZ)2{1‐MMTZ(H)}(2‐MMI){2‐MMI(H)2}] (5) were synthesised from imidazole‐, thiazole‐, thiadiazole‐, triazole‐, tetrazole‐ and pyrimidine‐based heterocyclic thiones. Four of these complexes 1–4 were synthesized from BiPh3, while complex 5 was obtained from Bi[4‐(MeO)Ph]3. Complexes 1–5 were structurally characterised by XRD. Evaluation of the antibacterial properties against Mycobacterium smegmatis, Staphylococcus aureus, Methicillin‐resistant S. aureus (MRSA), Vancomycin‐resistant Enterococcus (VRE), Enterococcus faecalis and Escherichia coli showed that mixed thiolato complexes containing the anionic thiazole‐based ligands MBT and 4‐BrMTD are most effective. The mixed thiolato complexes [Bi(MBT)2(5‐MMTD)] (3) having thiazole‐ and thiadiazole‐ and [Bi(4‐BrMBT)3{2‐MMI(H)}] (4) containing thiazole‐ and imidazole‐based ligands proved to be more efficient, with low minimum inhibitory concentrations of 1.73 and 3.45 µm for 3 against VRE and E. faecalis, respectively, and 2.20 µm for 4 against M. smegmatis and E. faecalis. All complexes showed little or no toxicity towards mammalian COS‐7 cell lines at 20 µg mL–1.

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Synthesis, Characterization and Microbial Activity of Chiral Mixed Ligand Transition Metal Complexes

Cited by 4 publications

References 9 publications

Untitled

Untitled

Mixed Ligand Co (II) Complexes: Use as Catalysts in the Hydrolysis of Esters

The Importance of Heterolepticity in Improving the Antibacterial Activity of Bismuth(III) Thiolates

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