Synthesis, Characterization and Molecular Docking of Novel Quinoline and Pyridine Derivatives

Saleh, Suheb Eaid; Altimari, Usama S.; Al-Fahdawi, Aeed S.; El-Khatatneh, Naseem; Chandra,; Mahendra, M.

doi:10.13005/ojc/330604

Cited by 3 publications

(1 citation statement)

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“…Group 6: burn treated with ointment for Staphylococcus aureus each (concentration 50 mg/mL) consisting of 0.5 g of Zn-complex added to 9.5 g of Vaseline.Group 7: burn treated with ointment for each bacteria (concentration 50 mg/mL) consisting of 0.5 g of Zn-complex added to 9.5 g of Vaseline. The treatment continued twice each day during 15 consecutive days and the numbers of bacteria was calculated [20,21].…”

Section: Inhibitory Effect Of Both Compounds On Staphylococcus Aureus and Salmonella Typhi (In Vivo)mentioning

confidence: 99%

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Al-Fahdawi

Al-Sorchee

Saleh³

et al. 2021

Egypt. J. Chem.

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In this research, the synthesis and biological activity evaluation of N, N`-(ethane-1,2-diyl)bis(1-phenyl methanimine) as Schiff base with Zinc (II) dithiocarbamate complex are successfully reported. The suggested geometry around zinc ion centre was determined using selected unique physicochemical and spectroscopic techniques. These include melting point, conductance, FTIR, UV-Vis, mass spectroscopy and 1 H-NMR spectroscopy. The analytical as well as the spectroscopic characterization data proves the formation of zinc complex with general formula [Zn(L)]2 and the complex of this ion is adopting tetrahedral geometry about the metal centre. Furthermore, the present study was carried out to evaluate antibacterial activity of obtained Schiff base ligand and Zn complex against five strains of bacteria (Staphylococcus aureus, Escherichia coli, Lacto bacillus, Klebsiella Pneumonae,and Salmonella typhi). The results of antimicrobial screening suggest that Schiff bases can show a considerable activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Salmonella typhi while Zn-complex was reported to be more active against all bacterial strains which is used in this test. The antibacterial activity of each compound has been examined practically (in vivo) by treating burns rats infected with tested bacteria (Staphylococcus aureus and Salmonella typhi), the results have shown signs of good recovery at short time if it compared with antibiotic Ofloxacin (OFX) used at the same time. And the number of bacteria was reduced significantly (P ≤ 0.001) during the treatment days. Furthermore, the results showed that Zn-complex is effective in treating various skin conditions; it is preferable to use it in the treatment of pathological injuries and against other skin infections.

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Section: Inhibitory Effect Of Both Compounds On Staphylococcus Aureus and Salmonella Typhi (In Vivo)mentioning

confidence: 99%

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Al-Fahdawi

Al-Sorchee

Saleh³

et al. 2021

Egypt. J. Chem.

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Optimizing and analysing the anti-cancer potential of novel quinoline acetohydrazide (QAH): A comprehensive study involving synthesis, structural evaluation, 3D energy frameworks, DFT calculations, in vitro and in silico evaluation

Al-Ostoot,

Akhileshwari,

Kameshwar

et al. 2025

Journal of Molecular Structure

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Synthesis, Characterization and Evaluation of fungial Activity of Copper(II) and Cobalt(II) Complexes with Imine Glutaraldehyde Derivatives.

Al-Fahdawi

Mohammed

Zaidan

2021

IOP Conf. Ser.: Mater. Sci. Eng.

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Two metal compolexes have been prepared throughout the reaction of copper(II) and cobalt(II) salts with the bidentate Schiff base synthesized from the reaction of two moles of o-toluidine and one mole of glutaraldehyde. These metal complexes have been characterized using physico-chemical techniques such as 1H-NMR, FTIR, Atomic Absorption A.A, CHN, UV-Vis spectra, magnatic susceptibility and conductivity measurements. The obtained results showed good agrrement with theoratical data and the geometry of both metal complexes was octagonal geometry. The biological activity have been tested using two types of fungus Aspergillus niger and Aspergillus parasiticus. Both metal complexes showed good activity against these two types of fumgus. Furthermore, antifungial activity of the synthesised metal complexes was better than antifungal drugs, Nystatin and Griseofulvin, which are used to treat both types of fungus.

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Synthesis, Characterization and Molecular Docking of Novel Quinoline and Pyridine Derivatives

Cited by 3 publications

References 0 publications

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Optimizing and analysing the anti-cancer potential of novel quinoline acetohydrazide (QAH): A comprehensive study involving synthesis, structural evaluation, 3D energy frameworks, DFT calculations, in vitro and in silico evaluation

Synthesis, Characterization and Evaluation of fungial Activity of Copper(II) and Cobalt(II) Complexes with Imine Glutaraldehyde Derivatives.

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