Synthesis, characterization and platelet adhesion studies of novel ion-containing aliphatic polyurethanes

Chen, Kuo Yu; Kuo, Jui‐Chao; Chen, Chu Yung

doi:10.1016/s0142-9612(99)00144-1

Cited by 73 publications

(33 citation statements)

References 35 publications

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“…The wettability of biomaterials is very important for their biocompatibility, especially hemocompatibility [46] and this also can influence the friction behaviour [47]. In general, hydrophilic surfaces provide good lubricity while surface hydrophobicity can lead to thrombogenesis arising from preferred fibrinogen adsorption activating adhesion of platelets and clotting [48].…”

Section: Surface Wettabilitymentioning

confidence: 99%

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Niemczyk

Fray

Franklin

2015

Tribology International

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The friction behaviour of new chitosan derivative coatings obtained by chemical modification of chitosan with fatty acids (linoleic and dilinoleic acid) has been investigated in order to explore their potential as endovascular catheter coatings and to benchmark them against commercially available coatings used in endovascular catheter applications. An in vitro tribological system was developed that was intended to represent to a limited extent the in vivo tribological conditions of a typical endovascular catheterization procedure. Continuous reciprocating sliding tests were carried out with uncoated and coated polymer specimens. The results showed that all of the coatings tested decreased the coefficient of friction compared to the uncoated polymer. Compared to a neat chitosan coating, the chitosan derivative coatings showed a clear reduction in the coefficient of friction to levels similar to those of the commercially-available coatings. A comparison between the friction results and contact angle measurements carried out on the coatings indicated that a range of contact angle values exists for which the friction coefficient is at a minimum. The reason for this is unclear and further studies are required in order to confirm and investigate the trend, especially within the context of hydrophilic lubricious coating development.

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Section: Surface Wettabilitymentioning

confidence: 99%

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Niemczyk

Fray

Franklin

2015

Tribology International

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“…[1][2][3][4] However, thrombus formation remained a critical risk factor. [5][6][7] An effective way to improve hemocompatibility of PCU is to optimize its material surface but not significantly change their intrinsic mechanical properties. Modification of the polyurethane surface chemistry combining reduced platelet adhesion/activation and increasing endothelial attachment would be an attractive task.…”

Section: Introductionmentioning

confidence: 99%

Plasma functionalization of polycarbonaturethane to improve endothelialization—Effect of shear stress as a critical factor for biocompatibility control

Lukas

Thomas²,

Gessner

et al. 2016

J Biomater Appl

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Medical devices made of polycarbonaturethane (PCU) combine excellent mechanical properties and little biological degradation, but restricted hemocompatibility. Modifications of PCU might reduce platelet adhesion and promote stable endothelialization. PCU was modified using gas plasma treatment, binding of hydrogels, and coupling of cellactive molecules (modified heparin, anti-thrombin III (ATIII), argatroban, fibronectin, laminin-nonapeptide, peptides with integrin-binding arginine-glycine-aspartic acid (RGD) motif). Biocompatibility was verified with static and dynamic cell culture techniques. Blinded analysis focused on improvement in endothelial cell (EC) adhesion/proliferation, antithrombogenicity, reproducible manufacturing process, and shear stress tolerance of ECs. EC adhesion and antithrombogenicity were achieved with 9/35 modifications. Additionally, 6/9 stimulated EC proliferation and 3/6 modification processes were highly reproducible for endothelialization. The latter modifications comprised immobilization of ATIII (A), polyethyleneglycole-diamine-hydrogel (E) and polyethylenimine-hydrogel connected with modified heparin (IH). Under sheer stress, only the IH modification improved EC adhesion within the graft. However, ECs did not arrange in flow direction and cell anchorage was restricted. Despite large variation in surface modification chemistry and improved EC adhesion under static culture conditions, additional introduction of shear stress foiled promising preliminary data. Therefore, biocompatibility testing required not only static tests but also usage of physiological conditions such as shear stress in the case of vascular grafts.

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“…Indeed, they have been used to prepare a variety of medical devices including blood bags, catheters, vascular grafts, and portions of artificial hearts [23,24]. However, PUs are not completely thromboresistant, as platelet adhesion/activation can still occur when in contact with blood for extended periods of time [21,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Polyurethane with tethered copper(II)–cyclen complex: Preparation, characterization and catalytic generation of nitric oxide from S-nitrosothiols

Hwang

Meyerhoff

2008

Biomaterials

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The preparation and characterization of a commercial biomedical grade polyurethane (Tecophilic, SP-93A-100) material possessing covalently linked copper(II)-cyclen moieties as a nitric oxide (NO) generating polymer are described. Chemiluminescence NO measurements demonstrate that the prepared polymer can decompose endogenous S-nitrosothiols (RSNOs) such as S-nitrosoglutathione and S-nitrosocysteine to NO in the presence of thiol reducing agents (RSHs; e.g., glutathione and cysteine) at physiological pH. Since such RSNO and RSH already exist in blood, the proposed polymer is capable of spontaneously generating NO when in contact with fresh blood. This is demonstrated by utilizing the polymer as an outer coating at the distal end of an amperometric NO sensor to create a device that generates response toward the RSNO species in the blood. This polymer possesses the combined benefits of a commercial biomedical grade polyurethane with the ability to generate biologically active NO when on contact with blood, and thus may serve as a useful coating to improve the hemocompatibility of various medical devices.

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Synthesis, characterization and platelet adhesion studies of novel ion-containing aliphatic polyurethanes

Cited by 73 publications

References 35 publications

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Plasma functionalization of polycarbonaturethane to improve endothelialization—Effect of shear stress as a critical factor for biocompatibility control

Polyurethane with tethered copper(II)–cyclen complex: Preparation, characterization and catalytic generation of nitric oxide from S-nitrosothiols

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