Synthesis, characterization and potential applications for oxidized agarose

Li, Chengpeng; Li, Xianzhu; Gu, Qixiang; Xie, Lici; Cheng, Ying; Liao, Lusheng

doi:10.1016/j.ijbiomac.2023.124643

Cited by 4 publications

(1 citation statement)

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“…The carboxyl group is both a donor and acceptor of hydrogen bonds. Therefore, after the carboxyl groups are introduced to the polysaccharide, the hydrogen bonds between intramolecular and intermolecular chains of polysaccharide are altered, leading to a change in the spatial conformation of the polysaccharide (Fu et al 2024;Li et al 2023). This change is crucial for regulating the thermosensitive properties of carboxylated polysaccharides.…”

Section: Carboxylated Polysaccharidesmentioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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In recent years, thermosensitive polysaccharide-based injectable hydrogels have gained increasing attention in biomedical applications, including wound healing, drug delivery, and cartilage repair. These hydrogels have favorable biocompatibility, biodegradability, and tunable physical and chemical properties. Thermosensitive polysaccharide-based injectable hydrogels are a class of intelligent soft matter material. They can undergo a reversible liquid-solid transition when exposed to temperature stimuli. Therefore, their precursor solutions can be accurately inserted into target sites with irregular geometries in a minimally invasive way and then transformed into gels in situ by the organism’s temperature stimulation to deliver biologically active molecules. This review summarizes the recent developments of thermosensitive injectable polysaccharide-based hydrogels. The focus is on the mechanism of sol-gel phase transition, as well as the design and preparation of thermosensitive polysaccharides and their applications in biomedical fields. In addition, the outlook of the challenges in biomedical applications is provided at the end of the paper.

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Section: Carboxylated Polysaccharidesmentioning

confidence: 99%