Synthesis, characterization and relaxivity validations of Gd(III) complex of DOTA tetrahydrazide as MRI contrast agent

Rajendran, Divya; Elizabeth, Judith; Manoharan, Sundar S; Vellala, Nagabhushan; Kootallur, Brahmadathan; Paul, Prince Makarios; Angamuthu, Abiram

doi:10.1016/j.molstruc.2022.132474

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…1 H NMR (400 MHz, CDCl 3 ): δ 3.92 (s, 2H), 1.49 (s, 9H). The obtained 1 H NMR spectrum was consistent with the report in the precedent literature [40]. HRESI-MS: m/z calculated for [M+ Na] + : 275.0; Found 275.0.…”

Section: Synthesis Of N-boc-2-bromoacetohydrazidesupporting

confidence: 89%

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Convenient and Controllable Synthesis of Poly(2-oxazoline)-Conjugated Doxorubicin for Regulating Anti-Tumor Selectivity

Zhou

Cui

Luo

et al. 2023

JFB

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Polyethylene glycol (PEG)–doxorubicin (DOX) conjugation is an important strategy to improve toxicity and enhance clinically therapeutic efficacy. However, with the frequent use of PEG-modified drugs, the accumulation of anti-PEG antibodies has become a tough issue, which limits the application of PEG–drug conjugation. As an alternative solution, poly(2-oxazoline) (POX)−DOX conjugation has shown great potential in the anti-tumor field, but the reported conjugation process of POX with DOX has drawbacks such as complex synthetic steps and purification. Herein, we propose a convenient and controllable strategy for the synthesis of POX−DOX conjugation with different chain lengths and narrow dispersity by N-boc-2-bromoacetohydrazide-initiated 2-ethyl-oxazoline polymerization and the subsequent deprotection of the N-Boc group and direct reaction with DOX. The DOX−PEtOx conjugates were firstly purified, and the successful conjugations were confirmed through various characterization methods. The synthetic DOX−PEtOxn conjugates reduce the toxicity of DOX and increase the selectivity to tumor cells, reflecting the promising application of this POX−DOX conjugation strategy in drug modification and development.

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Section: Synthesis Of N-boc-2-bromoacetohydrazidesupporting

confidence: 89%

“…N-boc-2-bromoacetohydrazide was synthesized according to the method in the previous literature [40], as shown in Scheme 1A. To a solution of t-butyl carbazate (5 g, 37.8 mmol, 1.0 equiv.)…”

Section: Synthesis Of N-boc-2-bromoacetohydrazidementioning

confidence: 99%

Convenient and Controllable Synthesis of Poly(2-oxazoline)-Conjugated Doxorubicin for Regulating Anti-Tumor Selectivity

Zhou

Cui

Luo

et al. 2023

JFB

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“…Wang et al showed that the luminous efficiency of CaF 2 : Nd co-doped Ce 3+ was 10.4 times higher than that of CaF 2 : Nd [47]. On the other hand, the seven unpaired electrons of Gd(III) can increase the proton relaxation rate, making Gd 3+ a common contrast agent in MR bioimaging [48,49]. Therefore, we choose Ce 3+ , Gd 3+ and Nd 3+ co-doping CaF 2 as the Pharmaceutics 2022, 14, 2796 3 of 18 material in our strategy to construct an imaging mode combining NIR-II imaging with complementary MRI and PAI.…”

Section: Introductionmentioning

confidence: 99%

Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications

Schomann

et al. 2022

Pharmaceutics

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Here, we describe the synthesis of a novel type of rare-earth-doped nanoparticles (NPs) for multimodal imaging, by combining the rare-earth elements Ce, Gd and Nd in a crystalline host lattice consisting of CaF2 (CaF2: Ce, Gd, Nd). CaF2: Ce, Gd, Nd NPs are small (15–20 nm), of uniform shape and size distribution, and show good biocompatibility and low immunogenicity in vitro. In addition, CaF2: Ce, Gd, Nd NPs possess excellent optical properties. CaF2: Ce, Gd, Nd NPs produce downconversion emissions in the second near-infrared window (NIR-II, 1000–1700 nm) under 808 nm excitation, with a strong emission peak at 1056 nm. Excitation in the first near- infrared window (NIR-I, 700–900 nm) has the advantage of deeper tissue penetration power and reduced autofluorescence, compared to visible light. Thus, CaF2: Ce, Gd, Nd NPs are ideally suited for in vivo fluorescence imaging. In addition, the presence of Gd3+ makes the NPs intrinsically monitorable by magnetic resonance imaging (MRI). Moreover, next to fluorescence and MR imaging, our results show that CaF2: Ce, Gd, Nd NPs can be used as imaging probes for photoacoustic imaging (PAI) in vitro. Therefore, due to their biocompatibility and suitability as multimodal imaging probes, CaF2: Ce, Gd, Nd NPs exhibit great potential as a traceable imaging agent in biomedical applications.

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Preparation and performance of biocompatible gadolinium polymer as liver-targeting magnetic resonance imaging contrast agent

Hu,

Wan,

Zhan

et al. 2024

Journal of Bioscience and Bioengineering

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Synthesis, characterization and relaxivity validations of Gd(III) complex of DOTA tetrahydrazide as MRI contrast agent

Cited by 5 publications

References 36 publications

Convenient and Controllable Synthesis of Poly(2-oxazoline)-Conjugated Doxorubicin for Regulating Anti-Tumor Selectivity

Convenient and Controllable Synthesis of Poly(2-oxazoline)-Conjugated Doxorubicin for Regulating Anti-Tumor Selectivity

Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications

Preparation and performance of biocompatible gadolinium polymer as liver-targeting magnetic resonance imaging contrast agent

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