Synthesis, characterization, and some pharmacological evaluation of 5-Thiocyanatouracil compound

Abstract

5-Thiocyanotouracil (5-TCU) was prepared in convenient method involved direct reaction of Potassium thiocyanate with 5-Iodouracil in refluxing aqueous solvent to give white crystalline in very good yield and high purity. This compound is important because it is similar in structure to 5-Flourouracil, which is of great importance as anti-cancer drug that is still used today. FT-IR, 1H- NMR, 13C- NMR, and CHN elemental analyses were used to describe the product. Median lethal dose LD50, in vitro antiradical activity and antibacterial effects were done. The results indicated that 5-TCU has relatively high LD50, non-significate antioxidant effect compare with ascorbic acid, and some antibacterial activity.

Synthesis of NiO nanoparticles from Paulownia tomentosa plant extracts via a green synthesis method and antibacterial, antibiofilm and cytotoxicity applications

“…The peak density of large particles is greater than that of small particles because large particles scatter much more light than smaller particles. 29 The sample surface morphology of the powder target material was assessed using SEM at magnifications of 1Âx and 10.00Âx. Analysis of the images indicates that the particles exhibit a high degree of agglomeration.…”