Synthesis, characterization and study of biological activity of some new 1, 2, 3, 4-Tetrazole derivatives.

Al-Labban, Hutham Mahmood Yousif

doi:10.5958/0974-360x.2017.00662.x

Cited by 7 publications

(4 citation statements)

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“…There are four essential proteins in granular cells, and one of them is eosinophil cationic protein, which stimulates the production of amino acid granules in the surrounding tissue (20). These findings are consistent with Tischendorf et al (21) who discovered that eosinophilic illnesses were the only conditions where ECP levels were raised.…”

Section: Discussionsupporting

confidence: 92%

“…Ferritin diminishes when an infectious process takes place because T. vaginalis uses ferritin as an iron source, as shown by the results from Fernando et al (9). According to Weinberg's study (21) T. vaginalis uses ferritin as a source of iron, which results in a drop in ferritin levels in the serum of men who have the infection compared to the control group (22). This finding is supported by the current study.…”

Section: Discussionsupporting

confidence: 83%

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Study the Role of Eosinophilic Cationic Protein, Copper and Iron in Women Infected with Trichomonas vaginalis Parasite

haider¹,

ALhadrawi²,

Al-Hadraawy³

et al. 2022

Journal of Pharmaceutical Negative Results

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Since Trichomonas vaginalis (T. vaginalis) only manifests as a trophozoite stage during sex, it is typically transmitted during sex as a trophozoite. The purpose of this study was to determine the concentrations of copper, iron, and Eosinophil cationic protein (ECP) in vaginitis patients. Between July and November 2021, 355 suspected patients who visited the AL-Zahra maternity and pediatrics laboratory in the AL-Najaf region (Iraq) and 30 healthy respondents of the same age participated in the study. According to the manufacturer's instructions, the ELISA technique was used to measure the levels of three biomarkers in serum (copper, iron, and ECP). On the other hand, the colorimetric approach was used to measure the copper concentration. The investigation showed that in the blood sample of T. vaginalis-infected patients, the amounts of copper and iron considerably decreased (P > 0.05). In contrast, the serum levels of ECP considerably increased (P > 0.05) when compared to the control group. As a result of the T. vaginalis infection, copper levels in the blood are dramatically impacted, according to the current study's findings. The current study results suggested that the T. vaginalis infection alters serum iron and ECP concentrations, significantly affecting copper levels in the blood.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Study the Role of Eosinophilic Cationic Protein, Copper and Iron in Women Infected with Trichomonas vaginalis Parasite

haider¹,

ALhadrawi²,

Al-Hadraawy³

et al. 2022

Journal of Pharmaceutical Negative Results

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“…An increase in the per cent of male infection may be due to males' behaviour in dealing with their surrounding environment. The category most movement, contact with external environmental factors in terms of their survival for a long time outside their homes to practice the business, which imperative them to eat and drink in crowded restaurants and shops that not clear and street vendors and play games more than female in addition to bad habits such as put fingers in the mouth and biting nails all these lead to increasing infect with the parasite especially in male so that the male is more susceptible than female (16,17,18,19,20,15,21,22,23). While Heideri and Rokni (24) and Al-fatli (25) refer to the absence of a significant difference in the incidence of the infection between males and females and other studies, found that the per cent of disease in females is more than males (26,27).…”

Section: Discussionmentioning

confidence: 99%

Incidence and age distribution of Giardia lamblia infection for sex years in Al-Najaf province in Iraq

Mohy¹,

Al-Hadraawy²,

hadi³

et al. 2022

Journal of Pharmaceutical Negative Results

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This study aimed to determine the prevalence of Giardia lamblia infection in Al-Najaf province, Iraq, based on various risk variables for sex years. From October 2015 to March 2021, samples were collected from suspected patients in the AL-Hakeem hospital and AL-Zahra maternity and paediatrics clinics in AL-Najaf province; stool samples were collected into clean, wide-mouth specimen bottles from suspected patients, and freshly voided stool specimens were processed and examined microscopically for intestinal paralysis. The current investigation found that 44 out of 44 (9.77%) patients were infected after detecting cyst and trophozoite of G. lamblia. The infection rate is proportional to the size of the family. Children from tiny families had the lowest infection rate (18.3%/15/82) and 18.3% (15/82). (4 persons). The infection rate gradually increased as family size grew, reaching 83.3 percent (5/6) in children from big households (12 persons). Based on the chi-square test, it was discovered that family size is non-significantly (P > 0.05) connected with pinworm infection.

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“…These pathogenic bacteria were provided from medical laboratory of Faculty of Science, University of Kufa, Iraq. Antibacterial activity test was performed by using agar well diffusion method [12,14]. Briefly, three concentrations were selected (50, 100 and 150 mg/mL) from each crud synthesized derivative compound.…”

Section: Biological Activity Testmentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Activity of Some New of Novel 1,2,3-Triazole-Chalcone Derivatives from N-Acetyl-5H-Dibenzo [b,f] Azepine-5-Carboxamide

Adam¹,

Al-Labban²,

Aljanaby³

et al. 2019

Nano BioMed ENG

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This work involves preparation of a series of 1,2,3-triazole derivatives. In the first step, the reaction of N-acetyl-5H-dibenzo [b,f] carboxamide with different benzaldehyde derivatives to yield chalcone compounds A-D was carried out. In the second step, compounds A-D reacted with 4,4' sulfonylbis(azidobenzene) (G) to produce 1,2,3-triazole derivatives A 1 -D 1 . All the prepared compounds were characterized by Fourier-transform infrared spectroscopy (FTIR) and melting point, some of them were characterized by proton nuclear magnetic resonance ( 1 H-NMR), spectroscopy analysis. Biological activity test was done to evaluate the antibacterial activity of eight synthesized derivative compounds against two multi-drug resistant pathogenic bacteria isolated from patients infected with burn infection; Staphylococcus aureus and Pseudomonas aeruginosa. Three concentrations were selected 50, 100 and 150 mg/mL from each of the synthesized derivative compounds. The derivative compound D 1 with the concentrations of 100 and 150 mg/mL exhibited excellent effect against P. aeruginoa with inhibition zone diameters of 28.10 ± 0.5 and 28 ± 0.05 mm, respectively.

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Synthesis, characterization and study of biological activity of some new 1, 2, 3, 4-Tetrazole derivatives.

Cited by 7 publications

References 0 publications

Study the Role of Eosinophilic Cationic Protein, Copper and Iron in Women Infected with Trichomonas vaginalis Parasite

Study the Role of Eosinophilic Cationic Protein, Copper and Iron in Women Infected with Trichomonas vaginalis Parasite

Incidence and age distribution of Giardia lamblia infection for sex years in Al-Najaf province in Iraq

Synthesis, Characterization and Antibacterial Activity of Some New of Novel 1,2,3-Triazole-Chalcone Derivatives from N-Acetyl-5H-Dibenzo [b,f] Azepine-5-Carboxamide

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