Synthesis, characterization and superoxide dismutase activity of bi-copper(II)-bisacetato- μ−phthalicacid[bis(benzyloxy)ethyl]ester

Sarma, Babita; Bhattacharyya, Pradip; Das, Diganta Kumar

doi:10.1007/s12039-015-0798-x

Cited by 2 publications

(2 citation statements)

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“…Copper complexes of salicylic acid are potent SOD mimetic as transition metal ion complexes have generally been used as antioxidants to eliminate noxious reactive oxygen species. Among the reported mimics, the highest SOD-like activity is only 20% of the bovine erythrocyte Cu, Zn-SOD [28]. Along with copper, some of the metals such as iron [29], manganese [29,30], ruthenium [31], and cobalt [32] show a marked SOD activity and seem to retain it in living cells which has been reported [33].…”

Section: Introductionmentioning

confidence: 89%

“…The scavenging effect of the Co(III) complexes may be ascribed to the chelating function of a ligand with the metal ion to achieve significantly selective effect of radical scavenging activity in biological system [63]. It has been proposed that only complexes with IC 50 values below 20 M may become clinically interesting [28]. Table S4 reveals the superoxide radical suppression efficacies of the complexes.…”

Section: Sod Assaymentioning

confidence: 99%

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Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Savithri

Kumar

Vivek³

et al. 2018

International Journal of Spectroscopy

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A bidentate (N- and O-) imine-based ligand(L1)and its metal complexes of types [CuII(L1)2](C1), [CuII(L1)(Phen)](C2), [CoIII(L1)2](C3), and [CoIII(L1)(Phen)](C4)(L1= 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes.In vitrobioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively byKbandKsvvalues which revealed a higher binding affinity for C2and C4as compared to C1and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

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Section: Introductionmentioning

confidence: 89%

Section: Sod Assaymentioning

confidence: 99%

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Savithri

Kumar

Vivek³

et al. 2018

International Journal of Spectroscopy

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Bovine Serum Albumin Metal Complexes for Mimic of SOD

Song

et al. 2016

J Chem Sci

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Superoxide anion radical (O •− 2) is a noxious reactive oxygen species (ROS). Transition metal ion complexes have been generally used as antioxidants to eliminate ROS. In this work, a neoteric watersoluble biopolymer metal complex (BSA-M) was prepared by conjugating the soluble biopolymer bovine serum albumin (BSA) with three transition metal ions (M, M=Cu, Co, Mn). The binding mode and ratio of metal ions bound to albumin were investigated. The BSA-M complexes were characterized by UV-Vis, circular dichroism (CD) spectra and polyacrylamide gel electrophoresis (PAGE). BSA served as polymer scaffold and the metal complex functioned as the catalytic active center. The results demonstrated that the structure of BSA remained unchanged when the binding ratio of transition metal ion complex to BSA was 5:1. Furthermore, the scavenging superoxide anion free radical (O •− 2) activity of biopolymer-metal complexes were determined by nitroblue tetrazolium light reduction assay method. The antioxidant capacity of BSA-M has markedly increased. The conjugated BSA-M (M=Cu, Mn) showed preeminent scavenging activity for O •− 2 , and the EC 50 value of the BSA-Cu was 0.038±0.0013 μmol•L −1 , which is comparable to EC 50 value (0.041±0.001 μmol•L −1) of the natural superoxide dismutase (SOD), the analog quantity reached 107%. As a consequence, it can be considered as a bio-functional mimic of enzyme SOD and has a promising application prospect in antioxidant drug field.

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Synthesis, characterization and superoxide dismutase activity of bi-copper(II)-bisacetato- μ−phthalicacid[bis(benzyloxy)ethyl]ester

Cited by 2 publications

References 32 publications

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Bovine Serum Albumin Metal Complexes for Mimic of SOD

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