Synthesis, characterization and theranostic evaluation of Indium-111 labeled multifunctional superparamagnetic iron oxide nanoparticles

Zolata, Hamidreza; Davani, F. Abbasi; Afarideh, H.

doi:10.1016/j.nucmedbio.2014.09.007

Cited by 45 publications

(26 citation statements)

References 29 publications

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“…90 Application of dipicolylamine alendronate magnetic nanoparticle tracer for localization of non-palpable breast lesions using a handheld magnetometer was developed as a clinical indication. This NS was prepared by radiolabeling of SPIONs with 99m Tc and alendronate after coating with biocompatible carboxydextran to prevent agglomeration and immune clearance.…”

Section: Radiolabeled Mnpsmentioning

confidence: 99%

Radiolabeled theranostics: magnetic and gold nanoparticles

et al. 2016

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Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems. Functionalized magnetic and gold NPs (MNPs and GNPs, respectively) have produced the potential of nanoparticles as sensitive multifunctional probes for molecular imaging, photothermal therapy and drug delivery and targeting. Methods: In this study, we review the most recent works on the improvement of various techniques for development of radiolabeled magnetic and gold nanoprobes, and discuss the methods for targeted imaging and therapies. Results: The receptor-specific radiopharmaceuticals have been developed to localized radiotherapy in disease sites. Application of advanced multimodal imaging methods and related modality imaging agents labeled with various radioisotopes (e.g., 125I, 111In, 64Cu, 68Ga, 99mTc) and MNPs/GNPs have significant effects on treatment and prognosis of cancer therapy. In addition, the surface modification with biocompatible polymer such as polyethylene glycol (PEG) have resulted in development of stealth NPs that can evade the opsonization and immune clearance. These long-circulating agents can be decorated with homing agents as well as radioisotopes for targeted imaging and therapy purposes. Conclusion: The modified MNPs or GNPs have wide applications in concurrent diagnosis and therapy of various malignancies. Once armed with radioisotopes, these nanosystems (NSs) can be exploited for combined multimodality imaging with photothermal/photodynamic therapy while delivering the loaded drugs or genes to the targeted cells/tissues. These NSs will be a game changer in combating various cancers.

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Section: Radiolabeled Mnpsmentioning

confidence: 99%

Radiolabeled theranostics: magnetic and gold nanoparticles

et al. 2016

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“…Conjugation with 111 In-labeled antimesothelin antibody mAbMB provided the SPIONs with the capacity to localize and image mesothelin-expressing cancer cells with both SPECT and MR imaging modalities [74]. Zolata H. et al (2015) decorated the surface of SPIONs with APTES, PEG and then conjugated thiolated bifunctional chelator 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9,-triacetic acid (PCTA). Furthermore, the nanoplatform was actively targeted with the monoclonal antibody trastuzumab, and drug-loaded with doxorubicin.…”

Section: Indium-111mentioning

confidence: 99%

“…Furthermore, the nanoplatform was actively targeted with the monoclonal antibody trastuzumab, and drug-loaded with doxorubicin. Further studies proved their accumulation in tumors due to the EPR effect and HER2 receptor targeting, as well as their efficacy as therapeutic agents in breast cancer animal models [75]. In order to exploit the advantages provided by triple-modal imaging, Bai J. et al (2016) designed magnetic nanocapsules (NCs) loaded with hydrophobic SPIONs.…”

Section: Indium-111mentioning

confidence: 99%

Radiolabeled Nanoparticles in Nuclear Oncology

2018

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A B S T R A C TDuring recent years, a plethora of pioneering radiolabeled nanoparticles have grown to be an integral part of nuclear medicine as theranostic tools. Herein, we focus on the most representative examples of nanoparticles of the past decade, which have been investigated in conjunction with radioisotopes aiming to serve as drug delivery or imaging agents. The present review highlights the key attributes of each nanosystem and the following classification of radiolabeled nanovehicles is based on increasing mass number (A) of radioisotopic elements.

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“…Also the FeS particles attached to PEG molecules showed higher r2 relaxivity than the Iron Oxide Particles (IONs) and thus prove to be a better diagnostic agent also. Zolata et al worked with SPION, in which NPs were heavily functionalized to equip them with almost all functions possible 72. SPIONs surface was altered with 3‐Aminopropyltriethoxy Silane (APTES) and PEG on their surface to increase the half‐life and reduce toxicity.…”

Section: Functionalization To Enhance Theranosticsmentioning

confidence: 99%

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

et al. 2016

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Functionalization enhances the properties and characteristics of nanoparticles through surface modification, and enables them to play a major role in the field of medicine. In molecular imaging, quality functional images are required with proper differentiation which can be seen with high contrast to obtain viable information. This review article discusses how functionalization enhances molecular imaging and enables multimodal imaging by which images with combination of functions particular to each modality can be obtained. This also explains how nanoparticles interacting at molecular level, when functionalized with molecules can target the cells of interest or substances with high specificity, reducing background signal and allowing simultaneous therapies to be carried out while imaging. Functionalization allows imaging for a prolonged period and enables to track the cells over a period of time. Recent researches and progress in functionalizing the nanoparticles to specifically enhance bioimaging with different modalities and their applications are reviewed in this article.

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Synthesis, characterization and theranostic evaluation of Indium-111 labeled multifunctional superparamagnetic iron oxide nanoparticles

Cited by 45 publications

References 29 publications

Radiolabeled theranostics: magnetic and gold nanoparticles

Radiolabeled theranostics: magnetic and gold nanoparticles

Radiolabeled Nanoparticles in Nuclear Oncology

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

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