Synthesis, characterization and thermal behavior of copper(II) complexes with pyridoxal thiosemi (PLTSC)- and S-methylisothiosemicarbazone (PLITSC)

Vojinović-Ješić, Ljiljana S.; Rodić, Marko V.; Holló, Berta Barta; Ivković, Sonja; Leovac, Vukadin M.; Szécsényi, Katalin Mészáros

doi:10.1007/s10973-015-4891-7

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…Four complex compounds bearing the same PLTSC ligand were selected to investigate the effect of metal ions on the structural parameters (Figure 1). Fe-PLTSC, Co-PLTSC, and Cu-PLTSC crystal structures were taken from the Cambridge Crystallographic Data Center (CCDC) [28,29,37]. At the same time, the described procedure for synthesizing Ni-PLTSC led to a slightly different structure than the one previously obtained [19].…”

Section: Crystal Structure Of Ni-pltsc Analysismentioning

confidence: 99%

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The Effect of Metal Ions (Fe, Co, Ni, and Cu) on the Molecular-Structural, Protein Binding, and Cytotoxic Properties of Metal Pyridoxal-Thiosemicarbazone Complexes

Jevtović

Alshamari

Milenković

et al. 2023

IJMS

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Thiosemicarbazones and their transition metal complexes are biologically active compounds and anticancer agents with versatile structural properties. In this contribution, the structural features and stability of four pyridoxal-thiosemicarbazone (PLTSC) complexes with Fe, Co, Ni, and Cu were investigated using the density functional theory and natural bond orbital approach. Special emphasis was placed on the analysis of the donor atom−metal interactions. The geometry of compounds and crystallographic structures were further examined by Hirshfeld surface analysis, and the main intermolecular interactions were outlined. It has been shown that the geometry and the number of PLTSC units in the structure determine the type and contribution of the specific interactions. The binding of all four complexes to bovine and human serum albumin was investigated through spectrofluorometric titration. The dependency of the thermodynamic parameters on the present metal ion and geometry was explained by the possible interactions through molecular docking simulations. The binding of complexes to DNA, as one of the possible ways the compounds could induce cell death, was examined by molecular docking. The cytotoxicity was measured towards HCT116, A375, MCF-7, A2780, and MCF5 cell lines, with Cu-PLTSC being the most active, as it had the highest affinity towards DNA and proteins.

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Section: Crystal Structure Of Ni-pltsc Analysismentioning

confidence: 99%

“…Yield: 0.20 g (58%). For the other three compounds, the procedure described in the literature was applied [19,28,29,37]. The compounds were recrystallized and used as obtained.…”

Section: Synthesis Of Investigated Compoundsmentioning

confidence: 99%

The Effect of Metal Ions (Fe, Co, Ni, and Cu) on the Molecular-Structural, Protein Binding, and Cytotoxic Properties of Metal Pyridoxal-Thiosemicarbazone Complexes

Jevtović

Alshamari

Milenković

et al. 2023

IJMS

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“…This phenomenon is further confirmed by magnetic moments values. Also, the g||/A|| values considered as a diagnostic of stereochemistry [39], in the range reported for tetragonal distorted octahedral complexes 150 to 250 cm -1 . The calculated orbital publications for the cobalt(II) complexes (6) indicates a d(x2-y2) ground state [40]which shows isotropic spectra with values 2.15 confirmed octahedral structure [35,40].…”

Section: Electron Spin Resonance (Esr)mentioning

confidence: 98%

Binuclear transition metal complexes containing 6 N moieties Schiff base ligand: Synthesis, characterization and microbicide activities

El-Gamasy¹,

Abd-ElRazek²

2023

Bull. Chem. Soc. Eth.

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ABSTRACT. Complexes of Co(II), Ni(II) and Cu(II) ions with tetra amine hydrazide ligand [H4L] were prepared and characterized using physical and spectral methods. Analytical data showed that the complexes found in (1:2) ligand:metal ratio. Spectral studies revealed that the ligand bonded to the metal ion in neutral tetradentate or tetrabasic tetradentate manner through azomethine nitrogen atom, protonated/deprotonated hydroxyl group. From the electronic spectral data together with magnetic susceptibility values a distorted octahedral structure can be proposed for all complexes except complex 2 which has square planar structure. Electron spin resonance spectra for Co(II) complex 6 revealed axial symmetry with g|| > g⊥ > ge, indicating distorted octahedral or square planar structures and the unpaired electron exists in a d(x2−y2) orbital with marked covalent bond feature. Quantum chemical calculations have been performed to study structures and energetics of the ligand and its complexes. The prepared complexes showed good to excellent antimicrobial activity, and the most active complexes against Aspergillus niger were 3 with zone of inhibition of 23 mm. Complex 7 showed interesting activity against Escherichia coli with zone of inhibition of 23 mm. KEY WORDS: Metal complexes, Nitrogen moiety, Antimicrobicide activity Bull. Chem. Soc. Ethiop. 2023, 37(4), 901-915. DOI: https://dx.doi.org/10.4314/bcse.v37i4.8

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“…A shift in the C=S band in the metal complexes from 841 cm -1 of PLTSC indicate the coordination of sulphur to the metal ion. [43] Dipeptides are coordinated in tridentate mode via nitrogen of free amino group, nitrogen of peptide nitrogen and oxygen of deprotonated carboxyl group. Existence of the free dipeptides as zwitter ions in the solid state is confirmed by a medium intensity band near 2100 cm -1 region, due to δ(NH3 + ) and ρ(NH3 + ).…”

Section: Ir Spectramentioning

confidence: 99%

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Saritha

Reddy

Sireesha

2021

Vietnam Journal of Chemistry

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The synthesis, characterization of mixed ligand chelates of Ni(II), [NiAL] involving Pyridoxalthiosemicarbazone (A) and dipeptides (L) viz., glycyl‐glycine (gly‐gly), glycyl‐L‐leucine (gly‐leu), glycyl‐L‐tyrosine (gly‐tyr) and glycyl‐L‐valine (gly‐val) and their biological activities have been studied. The complexes were characterized based on their elemental analysis, LC‐MS, IR, UV‐Vis spectral studies, magnetic moment, molar conductance and thermal analysis. The mixed ligand complexes were formed with 1:1:1 (Ni:A:L) ratio. The molar conductance data reveal the non‐electrolytic nature of the metal chelates. IR spectra show that the ligands are coordinated to the metal ion in a tridentate manner, involving O,N,S and O,N,N donor sites of ligands, A and L respectively. Based on the analytical data, octahedral geometry has been proposed for the metal complexes. DNA binding properties of the complexes have been investigated by UV‐Vis and fluorescence spectroscopy and also by viscosity measurements. The obtained results indicate that the complexes bind to DNA through intercalation mode, which is further validated by molecular docking studies. The hydrolytic cleavage of the pBR322 DNA from supercoiled to nicked form, by the metal complexes was investigated by gel electrophoresis technique. The metal complexes were also screened for their antioxidant, anti‐inflammatory and antibacterial activities and the findings have been reported.

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Synthesis, characterization and thermal behavior of copper(II) complexes with pyridoxal thiosemi (PLTSC)- and S-methylisothiosemicarbazone (PLITSC)

Cited by 11 publications

References 33 publications

The Effect of Metal Ions (Fe, Co, Ni, and Cu) on the Molecular-Structural, Protein Binding, and Cytotoxic Properties of Metal Pyridoxal-Thiosemicarbazone Complexes

The Effect of Metal Ions (Fe, Co, Ni, and Cu) on the Molecular-Structural, Protein Binding, and Cytotoxic Properties of Metal Pyridoxal-Thiosemicarbazone Complexes

Binuclear transition metal complexes containing 6 N moieties Schiff base ligand: Synthesis, characterization and microbicide activities

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

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