In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8 AE 1.0 mV decade À1 ) in a concentration range of 1 10 À6 to 1 10 À3 M with a detection limit of 8 10 À7 mol L
À1. The potential response of the electrode was constant in the pH range of 1.0-5.0. The electrode demonstrated a response time of~30 s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples.