SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL ACTIVITY AND ACUTE TOXICITY TEST OF A NOVEL 4̄,4̄̄ - (4, 5, 6, 7-TETRAHYDRO- [1, 2, 3 -] SELENAD IAZOLO [4, 5 e] PYRIDINE-4, 6-DIYL) BIS(BENZENE-1, 3-DIOL)

Neamah, Nadheerah F.; Khudair, Abdul-Razzak Naaeem; Al-Jadaan, Shaker A. N.

doi:10.21608/ejchem.2019.11702.1753

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“…1. Schematic illustration of the synthesis path way for preparation of novel selena-diazole derivative (Neamah et al, 2020) compound (T) compound was previously synthesized, characterized and identified. FT-IR spectra, melting point and TLC were measured in the department of Pharmaceutical Chemistry, College of Pharmacy/ University of Basrah/ Iraq.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant activity of novel selena-diazole derivative against oxidative stress induced by dipyrone in female rats

2020

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Introduction: Selena-diazole has antioxidant, and antitumor activities. Also selena-diazol exhibited promising antifungal, antibacterial, viral infection and neurodegenerative disease. The aim of the study is to evaluate the antioxidant activity of a novel -(4,5,6,7-tetrahydro- [1,2,3-] selenadiazolo [4,5 e] pyridine-4,6-diyl) bis(benzene-1,3-diol) (T) against dipyrone (Di) induced oxidative stress. Methods: In vitro antioxidant using DPPH, concentrations of T and ascorbic acid (AA) at 10, 20, 30, 40 and 50μg was measured. In vivo study conducted using four groups, received 50mg/kg of T or/and Di and DW for 30 days. Antioxidant estimated in vivo by serum superoxide dismutase activity (SOD); Glutathione Peroxidase enzyme GPx measured by using Rat SOD1 kit and Rat GPX1 ELISA Kit respectively. Furthermore, Malondialdehyde (MDA) is reliable biomarkers to predict oxidative stress. Results: The results indicate IC50 rate using DPPH of T compound 48.888μg/ml. GPx of T and T&Di groups were significantly increased. SOD of T was significantly increased than other groups. MDA results presented essential reduction in T group value than Di group. Conclusion: The study concluded that synthesized novel selena-diazole derivative T has a good effect as an anti-oxidant.

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Section: Introductionmentioning

confidence: 99%

“…1H-NMR and 13C-NMR spectra of (T) compound was recorded using Bruker Ultra shield spectrophotometer (300 MHz), University of Al-al-Bayt, Jordan. Median lethal dose and antimicrobial activity also measured (Neamah et al, 2020). The pathway of the synthesis illustrated in Figure 1.…”

Section: Introductionmentioning

confidence: 99%