2015
DOI: 10.4172/2155-9619.s8-004
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Synthesis, Characterization, Biodistribution and Scintigraphic Evaluation of Technetium-99m (99mTc) Labeled Pazufloxacin (PZN): A Novel Infection Radiotracer

Abstract: In this study tagging of 99m Tc with PZN was examined with regards to different concentration of PZN, stannous chloride, 99m Tc and pH ranges from 5.00-6.00. The suitability of the 99m Tc labeled PZN was assessed in terms of percent radiochemical purity (%RCP) yield in normal saline at concentration value of the stannous chloride as 120 mg, stability in serum (in vitro) at 37°C at different intervals, in vitro up take by live and heat killed E. coli, biodistribution behavior in artificially E. coli (live and h… Show more

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