Synthesis, characterization, coordination and antibacterial properties of novel asymmetric 1,1′‐disubstituted ferrocene‐derived Schiff‐base ligands and their Co(II), Cu(II) Ni(II) and Zn(II) complexes

Abstract

Some new asymmetric 1,1'-disubstituted ferrocene-derived Schiff-bases have been prepared and used as ligands in the preparation of their Co(II), Cu(II), Ni(II) and Zn(II) metal chelates. These synthesized ligands and their metal chelates have been characterized by their physical, analytical and spectral data. These have also been used for screening against pathogenic bacterial species, e.g. Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonae and have been found to be a novel class of organometallic-based antibacterials.

A Study on Antitubercular and Antimicrobial Activity of Isoniazid Derivative

“…The Schiff bases ligand was readily prepared for evaluation against M. tuberculosis in good yield. Compound show strong level of activity in vitro [22,23].…”

Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases

“…This process, in turn, increases the lipophilic nature of the central metal atom, which favors its permeation more efficiently through the lipid layer of the microorganism [44] thus destroying them more aggressively. The minimum inhibitory concentration mg/mL 21 was shown by compounds ranging from 10-100 mg/mL 21 against all the microbial strains are given in Table VI.…”

New lanthanide complexes of 1,1`-bis[(2-thienylmethylidene)hydrazono-1-ethyl]-ferrocene and 1,1`-bis(2,3-dihydro-2-methylbenzo[d]thiazol-2-yl)ferrocene: Synthesis, characterization and antimicrobial properties

“…In the UV-Vis spectra, a broad band centered at 456 nm was noted for the ligand. This band was attributed to charge transfer 1 A1g → 1 E1g in the ferrocenyl group (transition of the 3d electrons on iron to either the nonbonding or the antibonding orbitals of the cyclopentadienyl ring) [21]. The ligand is red in color, soluble in MeOH, C2H5OH, dimethylformamide, CH2Cl2 and CHCl3 and it was purified by crystallization from CHCl3.…”