Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine‐based two copper(II) compounds

Abstract

Two novel copper(II) complexes, [Cu(L)(Cl) 2 ](H 2 O) (1) and [Cu(L)(N 3 ) 2 ] (2), have been synthesized from a morpholine-based N,N,N donor tridentate Schiff base ligand, (E)-N-(2-morpholinoethyl)-1-phenyl-1-(pyridin-2-yl)methanimine (L). Ligand (L) and its stabilized complexes, 1 and 2, have been comprehensively characterized by different physical and spectroscopic techniques. Solidstate single-crystal X-ray structures of both 1 and 2 have been determined. Powder X-ray diffraction studies on the bulk samples of 1 and 2 have been executed to demonstrate that the synthesized bulk materials retain their solidphase purity as that exists in the single crystals. Cyclic voltammetric experiments have been done to demonstrate the redox behaviour of 1 and 2. UV-vis spectra of the copper(II) complexes with variation in time were accrued to probe that both 1 and 2 retain their stability in solution. Thermogravimetric analysis (TGA) has been performed to collate the thermal stability of 1 along with its possible thermal degradation behaviour. Room temperature magnetic moments of 1 and 2 have been determined. Cytotoxic activity of 1 and 2 has been screened against non-small human lung cancer cell, A549.

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu3OH core with regard to aspects of antiproliferative activity and magnetic properties

“…13 Recently, morpholine based mononuclear Cu( ii ) complexes have been screened by us against lung cancer cell lines A549. 14 Copper( ii ) complexes with the Schiff base ligand manifest commendable biological activities due to high DNA binding affinity and biocompatible redox potential. 15 The possible mechanisms of action of such complexes as anticancer agents are DNA interaction through non-covalent mode, generation of reactive oxygen species (ROS) and mitochondrial toxicity.…”