Synthesis, characterization, DNA binding and cleavage, HSA interaction and cytotoxicity of a new copper(II) complex derived from 2-(2′-pyridyl)benzothiazole and glycylglycine

Fu, Xia-Bing; Weng, Gui-Tian; Liu, Dandan; Le, Xueyi

doi:10.1016/j.jphotochem.2013.12.002

Cited by 64 publications

(15 citation statements)

References 52 publications

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“…The 4-(3, 4-dicyanophenoxy)-3-methoxybenzoic acid (3) compound was synthesized according to a method reported in the literature [26]. A mixture of 4-hydroxy-3-methoxybenzoic acid 1 excess (0.650 g) and 4-nitrophthalonitrile 2 (0.500 g, 2.89 mmol) in 15 mL dimethylsulfoxide (DMSO) was mixed under N 2 at 25 °C.…”

Section: -(3 4-dicyanophenoxy)-3-methoxybenzoic Acid (3)mentioning

confidence: 99%

“…The 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) complex was synthesized according to a procedure reported in the literature [26]. A mixture of 4-(3,4-dicyanophenoxy)-3-methoxybenzoic acid 3 (0.050 g, 0.…”

Section: The 2101624-tetrakis (Phenoxy-3-methoxybenzoic Acid)phthamentioning

confidence: 99%

“…The 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid) phthalocyaninato) Co(II) complex was synthesized according to a method reported in the literature [26]. The synthesis method used for compound 4 was repeated with CuCl 2 and with 5 min.…”

Section: The 2 10 16 24-tetrakis (Phenoxy-3-methoxybenzoic Acid)phmentioning

confidence: 99%

“…In this study, tetra phenoxy-3-methoxybenzoic acid substituted cobalt (II) (4) and copper (II) (5) complexes of phthalocyanine were synthesized and characterized by NMR, FT-IR and UV/Vis spectroscopy according a method reported in the literature [26]. The binding activities of the DNA with the complexes 4 and 5 were studied by UV/Vis, fluorescence spectroscopy, thermal melting, gel electrophoresis and viscosity measurements using the DNA in a buffer solution at pH 7.02 at 25 °C.…”

Section: Introductionmentioning

confidence: 99%

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DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

et al. 2020

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Tetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.

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Section: -(3 4-dicyanophenoxy)-3-methoxybenzoic Acid (3)mentioning

confidence: 99%

Section: The 2101624-tetrakis (Phenoxy-3-methoxybenzoic Acid)phthamentioning

confidence: 99%

Section: The 2 10 16 24-tetrakis (Phenoxy-3-methoxybenzoic Acid)phmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

et al. 2020

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“…76,192 Além disso, de acordo com a literatura as alterações conformacionais observadas na estrutura secundária da HSA resultam em um aumento na exposição de algumas regiões hidrofóbicas. 193,194 Como reportado anteriormente a ligação formada entre o complexos trinuclear e a proteína apresenta caráter hidrofóbico.…”

Section: Análise Conformacional Da Hsa Por Espectroscopia De Dicroísmunclassified

Complexos trinucleares de rutênio com ponte -oxo contendo ligantes N-heterocíclicos e monóxido de carbono: síntese, caracterização e estudo de interação com biomoléculas

Moreira¹

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AGRADECIMENTOSPrimeiramente agradeço à Prof. Dra. Sofia Nikolaou pela oportunidade de trabalhar em seu grupo, pela dedicação, atenção e pelos conhecimentos transmitidos. Sou e sempre serei grata por tudo que a professora me proporcionou neste tempo de aprendizado e amadurecimento científico.Ao Prof. Dr. Roberto Santana da Silva, pela amizade, pela confiança, pela acolhida em seu laboratório, pelas discussões científicas, pelas contribuições realizadas no exame de qualificação e pelo uso dos reagentes e equipamentos.Ao Prof. Gregóire Jean-François Demets, pelos conhecimentos transmitidos e pelas contribuições realizadas em meu exame de qualificação.Ao Prof. Dr. Elia Tfouni, pelos conhecimentos e materiais de fotoquímica.Ao Prof. Dr. Victor Marcelo Deflon (IQ-USP -São Carlos), pela colaboração na obtenção dos resultados de difração de raios-X. Aos meus irmãos queridos José Maria, Jú e Marta, por serem meu porto seguro, meu amparo em todos os momentos desde os meus primeiros passos, por acreditar em mim, pelo amor, carinho e apoio constante. Estendo a minha gratidão aos meus cunhados Sérgio Akira e Marili pelo apoio e carinho.Aos meus amáveis sobrinhos Daniel e Leandro, por tornar meus dias mais coloridos.Aos meus Pais, "pai e mãe ouro de mina", pelo amor puro e incondicional. Não há palavras exatas para demonstrar a minha gratidão por tudo que fizeram por mim.À minha filha Maria Carolina, por ser compreensiva, amorosa, leal e amiga em todos os momentos.A todos que colaboraram direta ou indiretamente com a realização deste trabalho.

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Copper Complexes as Anticancer Agents

Franco¹,

Porchia²,

Tisato³

et al. 2021

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Following the great impetus provided by the discovery of the anticancer activity of cisplatin [ cis ‐diamminedichloridoplatinum(II)] in the 1960s, extensive search for alternative metal‐based drugs with improved pharmacological properties has been attempted. Actually, the outstanding efficacy showed by clinically approved Pt(II) compounds is counterbalanced by severe toxic effects on normal tissues, and by the early appearance of drug resistance phenomena. Among non‐Pt compounds, copper complexes are considered promising alternatives to platinum drugs as antitumor agents. In particular, the discovery of significant alterations in cancer cell copper metabolism and the different responses to copper between normal and tumor cells have paved the way for the development of copper‐based anticancer drugs. This article aims to summarize the extant literature on the most well‐studied classes of anticancer copper complexes, with special emphasis on research performed in the last 10 years, most relevant to the elucidation of the involved mechanisms of action and/or reporting on in vivo efficacy evaluations.

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Synthesis, characterization, DNA binding and cleavage, HSA interaction and cytotoxicity of a new copper(II) complex derived from 2-(2′-pyridyl)benzothiazole and glycylglycine

Cited by 64 publications

References 52 publications

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

Complexos trinucleares de rutênio com ponte -oxo contendo ligantes N-heterocíclicos e monóxido de carbono: síntese, caracterização e estudo de interação com biomoléculas

Copper Complexes as Anticancer Agents

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