Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine

Wang, Qin; Huang, Yu; Zhang, Jinsheng; Xia, Yang

doi:10.1155/2014/354138

Cited by 21 publications

(8 citation statements)

References 39 publications

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“…In this present work a cerium (III) complex of new Schiff base (E)-Nbenzylidene-4-methoxyaniline noted (P2-CeCl 3 ) has been synthesized and characterized by elemental analysis, IR, NMR and Mass spectral data [28][29][30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

Imanelakehal¹,

Farhihalamia²,

Saoussenlakehal³

et al. 2016

Orient. J. Chem

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Complex of cerium (III) with (E)-N-benzylidene-4-methoxyaniline is synthesized through a one-pot three-component reaction from aromatic aldehyde, aromatic amine and the CeCl 3 · 7 H 2 O, as an efficient catalyst. This cerium (III) complex is characterized by IR, 1H, and 13C NMRspectroscopy and mass-spectral data. Molecular structure, Mullikan charges, thermodynamic parameters; vibrational frequencies and intensities were calculated by Density Functional theory methods (B3LYP, B3PW91, mPW1PW91 and PBEPBE) using the SDD basis set. The comparison between the calculated and experimental data in order to attain the best quality and to predict the structure, the best performance in the vibration spectra perfected of the title compound, we have found that the harmonic vibration computed are in a good agreement with the observed in IR spectrum, for closest match we calculated optimal scaling factors can recommend for the IR spectral future predictions for unknown compounds of this class. In order to better comparison, we also root mean square values of the experimental and calculated IR bands are 16.64, 16.64, 17.45, 17.66 and the mean absolute percentage error values are 1.33, 1.39, 1.40, and 1.5 for B3LYP, B3PW91, mPW1PW91, and PBEPBE methods respectively.

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Section: Introductionmentioning

confidence: 99%

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

Imanelakehal¹,

Farhihalamia²,

Saoussenlakehal³

et al. 2016

Orient. J. Chem

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“…The studies above and several previous data show that kaempferol's different synthetic and natural derivatives also presented significant cancer-fighting effects against hepatocarcinoma cells [ 54 , 92 ].…”

Section: Anti-cancer Activities Of Kaempferol In Literature Cancer Typesmentioning

confidence: 80%

A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound

2022

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It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is a multifaceted illness coordinated by multiple external and internal mechanisms. Natural extracts with the fewest side effects have piqued the attention of researchers in recent years, attempting to create cancer medicines based on them. An extensive array of natural product-derived anti-cancer agents have been examined to find a successful method. Numerous fruits and vegetables have high levels of naturally occurring flavonoid kaempferol, and its pharmacological and biological effects have been studied extensively. Certain forms of cancer are sensitive to kaempferol-mediated anti-cancer activity, although complete research is needed. We have endeavored to concentrate our review on controlling carcinogenic pathways by kaempferol in different malignancies. Aside from its extraordinary ability to modify cell processes, we have also discussed how kaempferol has the potential to be an effective therapy for numerous tumors.

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“…The pathways of viral protein interaction with cytokine and cytokine receptor, chemokine signaling pathway [26], and necroptosis [27,28] were significantly enriched in bacterial sepsis, while the pathways of the antigen processing and presentation [29], lysosome, and NF-kappa B signaling pathway were significantly enriched in fungal sepsis, and these three pathways may be the body's immune response to fungal sepsis [30][31][32]. We have preliminarily revealed the response of the human immune system to sepsis caused by different pathogens.…”

Section: Bacterial Sepsis-and Fungal Sepsis-specific Gene Setsmentioning

confidence: 99%

Two Gene Set Variation Index as Biomarker of Bacterial and Fungal Sepsis

Zheng

Luo

et al. 2020

BioMed Research International

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Background. The incidence of sepsis has been increasing in recent years. The molecular mechanism of different pathogenic sepsis remains elusive, and biomarkers of sepsis against different pathogens are still lacking. Methods. The microarray data of bacterial sepsis, fungal sepsis, and mock-treated samples were applied to perform differentially expressed gene (DEG) analysis to identify a bacterial sepsis-specific gene set and a fungal sepsis-specific gene set. Functional enrichment analysis was used to explore the body’s response to bacterial sepsis and fungal sepsis. Gene set variation analysis (GSVA) was used to score individual samples against the two pathogen-specific gene sets, and each sample gets a GSVA index. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of sepsis. An independent data set was used to validate the bacterial sepsis-specific GSVA index. Results. The genes differentially expressed only in bacterial sepsis and the genes differentially expressed only in fungal sepsis were significantly involved in different biological processes (BPs) and pathways. This indicated that the body’s responses to fungal sepsis and bacterial sepsis are varied. Twenty-two genes were identified as bacterial sepsis-specific genes and upregulated in bacterial sepsis, and 23 genes were identified as fungal sepsis-specific genes and upregulated in fungal sepsis. ROC curve analysis showed that both of the two pathogen sepsis-specific GSVA indexes may be a reliable biomarker for corresponding pathogen-induced sepsis (AUC=1.000), while the mRNA of CALCA (also known as PCT) have a poor diagnostic value with AUC=0.512 in bacterial sepsis and AUC=0.705 in fungi sepsis. In addition, the AUC of the bacterial sepsis-specific GSVA index in the independent data set was 0.762. Conclusion. We proposed a bacterial sepsis-specific gene set and a fungal sepsis-specific gene set; the bacterial sepsis GSVA index may be a reliable biomarker for bacterial sepsis.

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Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine

Cited by 21 publications

References 39 publications

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound

Two Gene Set Variation Index as Biomarker of Bacterial and Fungal Sepsis

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