Synthesis, Characterization, Fluorescence, Electrochemical, Antimicrobial and Cytotoxic studies of Cobalt(II), Nickel(II) and Copper(II) Complexes with N-4-Methylphenyl (2,4-dihydroxyacetophenylideneimine)

Abstract

N-4-Methylphenyl (2,4-dihydroxy acetophenylideneimine) (NMEPDHAPI) complexes of Co(II), Ni(II) and Cu(II) have been synthesized and characterized. A study on their electrochemical, fluorescence and biological behaviour have also been performed. The complexes have been characterized on account of metal estimation studies, conductance behaviour, magnetic property, IR, UV-visible, EPR(Liquid nitrogen temperature) spectral studies and thermal analysis. The 1:2 metal : ligand complex formation is authenticated from the analytical data. Based on the various studies, the Co(II) complex has been recommended for octahedral geometry and a square planar geometry has been prompted for Cu(II) and Ni(II) complexes. The electro chemical property of the complexes have been studied by cyclic voltammetry. The Schiff base and its complexes have been scrutinized against bacterial and fungal pathogens. The complexes have been found to be more active than the Schiff base towards most of the pathogens studied. Invitro cytotoxicity of the copper complex of NMEPDHAPI has been screened against breast cancer cell lines (MCF-7). The IC50 value recommend that the copper complex has notable cytotoxicity against breast cancer cell line (MCF-7).

Highly Selective and Sensitive Dual Channel New Schiff base Chemosensor based on 5‐bromo‐2‐hydroxybenzaldehyde and its Co(II), Ni(II), Cu(II) and Zn(II) Complexes ‐ Synthesis, Spectral and Theoretical characterization and Pharmacological applications

“…[ 15 ] The sharp bands at 3348.48 cm ‐1 and 3288.63 cm ‐1 indicate the presence of phenolic –OH groups [ 16 ] and the bands at 1244.09 cm ‐1 and 1112.93 cm ‐1 are due to C–O stretching vibrations of phenolic groups. [ 17 ] The bands at 630.72 cm ‐1 , 717.73 cm ‐1 and 759.95 cm ‐1 evidence the presence of C‐Br bond. [ 18 ]…”

“…[15] The sharp bands at 3348.48 cm -1 and 3288.63 cm -1 indicate the presence of phenolic -OH groups [16] and the bands at 1244.09 cm -1 and 1112.93 cm -1 are due to C-O stretching vibrations of phenolic groups. [17] The bands at 630.72 cm -1 , 717.73 cm -1 and 759.95 cm -1 evidence the presence of C-Br bond. [18] The C=N stretching frequency observed at 1597.06 cm -1 in the ligand is shifted to 1600.92-1633.71 cm -1 in the complexes indicating the coordination of the azomethine nitrogen to the metal.…”