Synthesis, Characterization, Free Radical Scavenging and Cytotoxic Activities of Phenylvilangin, a Substituted Dimer of Embelin

Ganesh

2022

JPRI

Introduction: Glass ionomer cement is a restorative material used in dentistry as a filling material and luting cement. Nowadays many consumers have started using natural toothpaste in order to avoid synthetic and artificial products. The aim of this study is to compare the surface roughness of two commercially available glass ionomer cements after subjecting them to brushing simulation with herbal and fluoridated toothpaste. Materials and Methods: Glass ionomer cements of two different brands (D- tech and gold label) were moulded into small discs of custom sizes. Their surface roughness before subjecting them to brushing simulation was recorded using Mitutoyo SJ 310 stylus profilometer. Then the glass ionomer cement pellets were mounted on die stones. 4 samples of D-tech and 4 samples of gold label were taken. The mounted samples were placed in a tooth brush simulator (ZM3.8 SD Mechatronik). The samples were subjected to 30000 cycles of brushing with standard and herbal toothpastes. After brushing simulation the GIC samples were again checked for their surface roughness using the stylus profilometer. Results: The values were recorded and analysed in the SPSS software. The obtained results from the one way ANOVA test were depicted in the form of tables and graphs. Surface roughness of D-Tech Colgate group GIC samples was increased after brushing simulation. The p-value is 0.469 < 0.05, hence statistically not significant. Conclusion: From the results obtained we can conclude that gold label brand glass ionomer cement showed less surface roughness when compared to D tech brand glass ionomer cement after brushing simulation with herbal and fluoridated toothpaste.

Section: Methodsmentioning

confidence: 99%

Comparison of Surface Roughness of Two Commercially Available Glass Ionomer Cements after Brushing Simulation with Herbal and Fluoridated Toothpaste - An In vitro Study

Kishore

Ganesh

2022

JPRI

“…1 [6]. The complete synthetic procedure and characterisation of phenyl vilangin involving Mass and NMR were reported in our previous work [7]…”

Section: Synthesis Of Vilangin and Phenyl Vilanginmentioning

confidence: 99%

Molecular docking studies, in vitro-brine shrimp lethal assay and antibacterial assessment of embelin, vilangin and phenyl vilangin against endodontic pathogen, Enterococcus faecalis

Kandaswamy

Sukumar³

et al. 2021

Res Chem Intermed

Self Cite

Complete debridement and disinfection of the root canal system are the primary requirement for successful endodontic treatment. Enterococcus faecalis is the most commonly found organism in a high percentage of root canal failures as a single organism or as a major component of the flora. Primary goal of this study is to assess the antibacterial effect of phytochemical agents namely embelin, vilangin and phenyl vilangin, respectively, against E. faecalis. And this is the first time that these materials are reported for antibacterial activity against the pathogen, E. faecalis. Our second goal is to predict the interaction between the active structure and the protein in the binding mode, and the third goal is to screen for cytotoxicity by brine shrimp lethality bioassay. All the compounds showed low to elevated level of antibacterial activity. Particularly, compound embelin, as well as its combination with NaOCl in the ratio 1:1, exhibits zone of inhibition value of 29 ± 0.89 and 32 ± 0.98 mm at a concentration of 80 µL and the MIC value of embelin was found to be 78.10 µg/mL. All the compounds exhibit low toxicity to high toxicity. The LC 50 value of tested * S. Jayalakshmi

“…Many materials have come into dentistry for restoration material which have a good esthetic such that of the natural tooth and compressive stability of that of amalgam restoration [4,5]. Cention N is one such new product which is an alkasite based dental restorative material a resin-based self-curing powder liquid restorative material and it has the fluoride releasing ability which helps in the release of the hydroxyapatite in the tooth and helps in in the repair and remineralisation of the enamel, thus helping to prevent tooth sensitivity [6,7]. Cention-N is a novel bulk fill dental restorative material which can be used as self and light cure material.…”

Section: Introductionmentioning

confidence: 99%

Effect of Thermocycling on Colour Stability of Alkasite Restorative Material (Cention N) - An In Vitro Study

Kishore

Ganesh

2022

JPRI

Introduction: Cention N is an alkasite based dental restorative material, it is far less expensive unlike composite materials, it has fluoride releasing property and the strength of cention N is comparable to that of dental amalgam restorations. Colour stability is one of the major and important characteristics in dentistry, dental restoration and esthetics. The aim of the study is to evaluate the colour stability of alkasite restorative material (Cention N) before and after thermocycling. Materials and Methods: Eight disc shaped samples of alkasite restorative material Cention N with 2 mm of thickness were prepared using a customised mould. After the disc sample preparation, they were numbered for identification and color stability was measured by using Vita easy shade advance spectrophotometer. L, a and b values were obtained before the thermocycling procedure. 1000 cycles of thermocycling was done which is equal to 6 months. The thermocycler used was TC 4 SD Mechatronik. The colour stability value after thermocycling was again determined using the vita easy shade spectrophotometer. Control group samples were not subjected to thermocycling. The colour stability values prior and after thermocycling were obtained and tabulated. Results: Thermocycled cention N samples had low delta E values when compared to that of non thermocycled samples. Statistical analysis was done using spss software and independent t test was done. P value was found to be 0.616, showing that it is statistically insignificant. Conclusion: From this research we can conclude that thermocycling procedure has an effect on the colour stability of the cention N material. Thermocycled cention N samples had better color stability when compared to non thermocycled cention N samples.