Synthesis, characterization, HSA interaction, and antibacterial activity of a new water-soluble Pt(II) complex containing the drug cephalexin

Shahabadi, Nahid; Hashempour, Shokoufeh; Mohsenzadeh, Farshid

doi:10.1080/00958972.2018.1525488

Cited by 11 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In other words, the hyperchromicity seen in the absorption spectrum of zinc(II) complex‐protein indicates environmental variations of the tryptophan 214 residue and a slight increment in the hydrophobicity of the microenvironment of the tryptophan 214 residue [15] . Therefore, the zinc(II) complex‐HSA interaction leads to conformational variations in the albumin, so that the hydrophobicity around the aromatic amino acid residues increases and the peptide strings in the albumin expand [2,16] . Besides, such results presumably suggest the interaction of the zinc(II) complex with albumin to create a ground‐state conjugate, and they may show that fluorescence quenching is mostly a static quenching process [2] .…”

Section: Resultsmentioning

confidence: 99%

“…[2,16] Besides, such results presumably suggest the interaction of the zinc(II) complex with albumin to create a ground-state conjugate, and they may show that fluorescence quenching is mostly a static quenching process. [2] Figure 2 exhibits the electronic absorption spectrum of the zinc(II) complex alone.…”

Section: Investigation Of Electronic Absorption Spectramentioning

confidence: 95%

“…[1] HSA is stored in cancer cells, and its amount in these cells is much higher than healthy cells. [2] This protein has an excellent binding capacity to bind to diverse small compounds. The ultimate purpose of using HSA is to improve drug delivery for the treatment of human diseases.…”

Section: Introductionmentioning

confidence: 99%

“…HSA could potentially be a drug carrier; so, utilization of this protein as a drug‐ delivered system would be much advantageous, especially in cases of life‐threatening disorders such as diabetes, cardiovascular diseases, and cancer [1] . HSA is stored in cancer cells, and its amount in these cells is much higher than healthy cells [2] . This protein has an excellent binding capacity to bind to diverse small compounds.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Multi‐Spectroscopic and Theoretical Analyses of Human Serum Albumin Binding to a Water‐Soluble Zinc(II) Complex including β‐Amino Alcohol

et al. 2022

Self Cite

View full text Add to dashboard Cite

In this study, we examined the interaction process of human serum albumin (HSA) with a water-soluble zinc(II) complex of dichloro {2-[N-(2-hydroxyethylammonioethyl) imino methyl] phenol} at pH = 7.4 and in vitro utilizing molecular docking modeling and spectral techniques. In the multi-temperature fluorescence test, the consecutive and gradual addition of the zinc(II) complex to the HSA-containing cell resulted in fluorescence quenching, and it showed that the zinc(II) complex-protein interaction is associated with a static quenching mechanism; also, the number of binding sites (n) and the binding constant (K b ) were computed by this test. The evaluation of thermodynamic data showed spontaneous progression, and the involvement of hydrogen bonding/van der Waals forces in protein-zinc(II)complex formation. The site markers competition studies using two drugs, warfarin and ibuprofen, indicated that zinc(II) complex binds to the protein via site I/sub-domain IIA. The albumin-zinc(II) complex interaction and the structural alterations in the serum albumin were proved by electronic absorption technique and circular dichroism spectroscopy. Job's curve exhibited a stoichiometric ratio of 1 : 1 in the HSA-zinc(II) complex adduct. The accuracy of the results obtained from experimental findings on the interaction between HSA and zinc(II) complex was checked by molecular docking simulation, which illustrated a good agreement between experimental and theoretical data.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Investigation Of Electronic Absorption Spectramentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multi‐Spectroscopic and Theoretical Analyses of Human Serum Albumin Binding to a Water‐Soluble Zinc(II) Complex including β‐Amino Alcohol

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Apart from CeO 2 nanomaterials, new water‐soluble platinum(II) nanocomplexes with excellent antimicrobial properties have also been reported. [ 309 ] New nanosized Cr(III), Fe(II), Co(II), and Ni(II) complexes incorporating the 2‐((E)‐(pyridine‐2‐ylimino)methyl)napthalen‐1‐ol ligand have been synthesized that possess better antibacterial and antiviral properties than the free ligand. [ 310 ]…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

524

368

View full text Add to dashboard Cite

Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

show abstract

Experimental and Molecular Docking Studies on the Interaction of a Water-Soluble Pd(II) Complex Containing β-Amino Alcohol with Calf Thymus DNA

Shahabadi

Ghaffari

Mardani

et al. 2021

Biol Trace Elem Res

View full text Add to dashboard Cite

Synthesis, characterization, HSA interaction, and antibacterial activity of a new water-soluble Pt(II) complex containing the drug cephalexin

Cited by 11 publications

References 41 publications

Multi‐Spectroscopic and Theoretical Analyses of Human Serum Albumin Binding to a Water‐Soluble Zinc(II) Complex including β‐Amino Alcohol

Multi‐Spectroscopic and Theoretical Analyses of Human Serum Albumin Binding to a Water‐Soluble Zinc(II) Complex including β‐Amino Alcohol

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Experimental and Molecular Docking Studies on the Interaction of a Water-Soluble Pd(II) Complex Containing β-Amino Alcohol with Calf Thymus DNA

Contact Info

Product

Resources

About