Synthesis, characterization, in silico and in vitro biological activity studies of Ru(II) (η6-p-cymene) complexes with novel N-dibenzosuberene substituted aroyl selenourea exhibiting Se type coordination

Ruthenium Complexes with 2-Pyridin-2-yl-1H-benzimidazole as Potential Antimicrobial Agents: Correlation between Chemical Properties and Anti-Biofilm Effects

“…Whereas, the Ru(III/IV) complex activity remains at the same level regardless of the concentration used (74%). The Ru(II) complex is characterized by anti-biofilm activity amount of 46% (at concentration of 0.5 mM) despite the fact that arene-ruthenium complexes containing p -cymene ring are described in the literature as compounds with a very high antimicrobial and anticancer activities [ 45 , 46 , 47 , 48 ]. The lowest percent inhibition of biofilm formation is observed in the presence of the Ru(III) complex.…”

Metal-based compounds containing selenium: An appealing approach towards novel therapeutic drugs with anticancer and antimicrobial effects

“…N-dibenzosuberene-selenourea derivatives (112)(113)(114) in Fig. 8) were also evaluated for their antimicrobial potential, showing low MIC values almost comparable to those of standard drugs [175]. Likewise, a comparative study regarding a series of Au(I), Pd(II), and Ru(II) complexes featuring deprotonated thio-and seleno-ureato ligands was also reported [177].…”

“…In this context, the Ru η 6 -p-cymene precursor was modified by incorporating different N-dibenzosuberene (112)(113)(114) in Fig. 8) [175] or aniline (115)(116)(117) in Fig. 8) [176] substituted-selenoureas, in which only the Se atom was coordinated to the metal center in a monodentate neutral interaction.…”