Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of dinuclear Pd(II) and Pt(II) complexes dibridged by 2,2′-azanediyldibenzoic acid

Synthesis, characterization, DNA interaction, and cytotoxicity of novel Pd(II) and Pt(II) complexes

“…In fact, only a few crystal structures have been reported for Pt(NN) complexes 17,18 . Our group has reported crystal structures of the Pd(NN) type complexes 19,20 , where NN is phen or bipy, that are analogous to the present complex 1. The N(2)-Pd-Cl angle measures 173.07° and the N(1)-Pd-N(3) angle measures 176.03°, and therefore the coordination geometry of the Pd atom is square planar, with rather small deviations of the ligating atoms from the coordination plane.…”

DNA Binding Studies and Cytotoxicity of the Novel 1,10-phenanthroline Palladium(II) Complexes of Dithiocarbamate Derivatives

“…[26][27][28] The MTT assay is dependent on the cleavage and conversion of the soluble yellowish MTT to the insoluble purple formazan by active mitochondrial dehydrogenase of living cells. The leukemia cell line K562 was maintained in a RPMI medium supplemented with 10% heat-inactivated fetal calf serum and 2 mM L-glutamine, streptomycin and penicillin (5 µg/ ml), at 310 K under a 5% CO 2 /95% air atmosphere.…”

Anti-growth effect of a novel trans-dichloridobis[2-(2-hydroxyethyl)pyridine]platinum (II) complex via induction of apoptosis on breast cancer cell lines

“…Platinum therapy associated inadequacies such as acquired resistance [3] and toxic side effects [4] emphasizes the need for new anticancer drugs with new mechanisms of action. Several research groups showed that platinum (II) complexes have significant anti-tumor activities against different types of cancers in vitro and in vivo [5][6][7][8][9][10][11].…”