Synthesis, characterization of nitro or amino substituted pyridyl ligands bridged by an ester or ether bond, and their antibacterial assessment against drug resistant bacteria

Matshwele, James T.P.; Jongman, Mosimanegape; Koobotse, Moses O.; Mazimba, Ofentse; Mapolelo, Daphne T.; Nkwe, David O.; Nareetsile, Florence; Odisitse, Sebusi

doi:10.1016/j.rechem.2022.100401

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…The results showed that the inhibition zone produced by bis (-2-ethyl hexyl) phthalate against S. aureus was higher than E. coli, this was related to the chemical structure of the bis (-2-ethyl hexyl) phthalate compound. The ester functional group is known to improve the biological activity of drugs and this has been linked with various chemical properties of this functional (Matshwele et al, 2022). This bis (-2-ethyl hexyl) phthalate compound also has a benzene ring which makes it able to penetrate the lipid layer in the bacterial wall (Dharmayani et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Marine Sponge (Stylotella sp.)

Dharmayani,

Isnaini,

Ulfa

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Sponges are marine biota that makes up coral reefs that live on the bottom of the waters and have an important role in marine ecosystems. Sponges have bioactive components that have not been widely used by the community. This study aimed to analyze the content of secondary metabolites and the antibacterial activity of the sponge Stylotella sp. antibacterial activity test against Gram-negative (-) Escherichia coli and Gram-positive (+) Staphylococcus aureus was carried out using the good diffusion method. The results of antibacterial testing with various concentrations of 50, 100, and 150 ppm of the isolates showed that the zone of inhibition against E. coli was 11.3; 12; and 13 mm while for S. aureus was 12.3; 13; and 14 mm. The results of antibacterial testing with a concentration of 600 ppm of sponge extract showed an inhibition zone on E. coli and S. aureus in the amount of 13.3 and 14 mm, respectively. The test results showed that the sponge extract and isolate were in the intermediate category and were resistant to E. Coli bacteria. and S. Aureus

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Marine Sponge (Stylotella sp.)

Dharmayani,

Isnaini,

Ulfa

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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“…Triazine and methyl ester from aminobenzoic acid analogs were synthesized [59]. The esterified products of p-substituted nitro and amino benzoic acid were synthesized in the presence of potassium carbonate and dimethylformamide by the o-alkylation of the COOH group, followed by alkylation of p-nitrophenol and p-acetaminophen [60].…”

Section: Synthesis Of Antimicrobial Agentsmentioning

confidence: 99%

“…(A): Synthetic routes for derivatives of p-aminobenzoic acid having antimicrobial potential (adapted from refs. [30,31,38,[57][58][59][60][61][62][63]65,66]). (B): Synthetic routes of derivatives of p-aminobenzoic acid having antimicrobial potential (adapted from refs.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…These compounds showed greater inhibitory potential against E. coli and S. aureus comparable to ampicillin [59]. The antibacterial properties of the synthesized compounds were greater toward Gram-negative than Gram-positives, and amino derivatives were more effective with MIC values of 0.16 mM [60]. Preliminary in vitro antibacterial and antifungal activity was evaluated for all PABA-derivatized compounds, which exhibited notable antifungal and antibacterial activity.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Scheme 2. (A): Synthetic routes for derivatives of p-aminobenzoic acid having antimicrobial potential (adapted from ref [30,31,38,[57][58][59][60][61][62][63]65,66]…”

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confidence: 99%

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Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications

Haroon,

Farwa,

Arif

et al. 2023

Biomedicines

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A “building block” is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications. Anticancer, anti-Alzheimer’s, antibacterial, antiviral, antioxidant, and anti-inflammatory properties have been observed in PABA compounds, suggesting their potential as therapeutic agents in future clinical trials. PABA-based therapeutic chemicals as molecular targets and their usage in biological processes are the primary focus of this review study. PABA’s unique features make it a strong candidate for inclusion in a massive chemical database of molecules having drug-like effects. Based on the current literature, further investigation is needed to evaluate the safety and efficacy of PABA derivatives in clinical investigations and better understand the specific mechanism of action revealed by these compounds.

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