Synthesis, Characterization, Speciation, and Biological Studies on Metal Chelates of Carbohydrates with Molecular Docking Investigation

Khalf‐Alla, Perihan A.; Basta, Altaf H.; Lotfy, Vivian F.; Hassan, Safaa S.

doi:10.1002/mame.202000633

Cited by 15 publications

(13 citation statements)

References 65 publications

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“…Platinum (Pt) drugs are the most successful class of inorganic medicinal compounds used to treat cancer [47 and 48]. Numerous metals specially Pd (II) and Cu (II) complexes have promising activity against tumor cell lines have been synthesized and published [49][50][51][52][53][54]. In addition to vanadium which has a potential role in tumor growth inhibition and in prophylaxis against different experimental cancer models like; liver cancer, colon cancer, breast cancer and others and in various types of malignant cell lines.…”

Section: Cytotoxicity and Molecular Docking Investigationmentioning

confidence: 99%

“…[54,55] Numerous metal complexes have potent activity against tumor cell lines specially Pd (II) and Cu (II) complexes. [42,[56][57][58][59][60] Vanadium has a potential role in the growth inhibition of various tumor types such as breast, colon, liver, and cancer. The cytotoxicity against MCF-7 cancer cell line was carried out by using different concentrations (1-50 μg/ml) of the investigated Schiff base NBM and its metal chelates.…”

Section: Cytotoxicity and Molecular Docking Investigationmentioning

confidence: 99%

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The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Hassan

Bedir

Hamza

et al. 2022

Applied Organom Chemis

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Novel Schiff base was synthesized from condensation reaction of metformin with [4-(Diethylamino) benzaldehyde (NBM). Different metal complexes were prepared using Pd(II), Pt(II), Cu(II) and V(IV) metal ions. All complexes showed the non-electrolytic behavior. So, the expectedThe cytotoxicity of (NBM) Schiff base and its metal complexes on human cancer cell line, MCF-7, was investigated. V(IV) and Cu (II) complexes showed potential blood-glucose lowering effect higher than the commercial metformin drug. VO(IV) complex has superior antioxidant activity more than the other synthesized compounds and the standard ascorbic acid. Molecular docking investigation proved the presence of interesting interactions between all synthesized compounds with the active site amino acids of EGFR tyrosine kinase (anticancer activity). The molecular docking of metal complexes observed effective inhibition for the specific mTOR protein that is expected to aid the growth of the COVID-19 virus.

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Section: Cytotoxicity and Molecular Docking Investigationmentioning

confidence: 99%

Section: Cytotoxicity and Molecular Docking Investigationmentioning

confidence: 99%

The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Hassan

Bedir

Hamza

et al. 2022

Applied Organom Chemis

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“…Surprisingly, aerogel-based SIMs or SMMs have not yet been reported, and even aerogels that are modified with magnetic metal complexes have very rarely been mentioned. Khalf-Alla et al immobilized square planar Pd(II) and octahedral Cu(II) complexes in starch and carboxymethyl cellulose aerogels, to produce antimicrobial and anti-cancer materials [ 54 ]. He et al reported iron- and nitrogen-codoped carbon nanocomposites with single-copper sites to reduce the magnetic moment of iron centers and to enhance the electrocatalytic performance of the material [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Aerogel-Based Single-Ion Magnets: A Case Study of a Cobalt(II) Complex Immobilized in Silica

et al. 2023

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The chemical immobilization of cobalt(II) ions in a silica aerogel matrix enabled the synthesis of the first representative example of aerogel-based single-ion magnets. For the synthesis of the lyogels, methyl-trimethoxysilane and N-3-(trimethoxysilyl)propyl ethylenediamine were co-hydrolyzed, then the ethylenediamine groups that were immobilized on the silica matrix enabled the subsequent binding of cobalt(II) ions. Lyogels with various amounts of ethylenediamine moieties (0.1–15 mol %) were soaked in isopropanol solutions of cobalt(II) nitrate and further supercritically dried in carbon dioxide to obtain aerogels with a specific surface area of 210–596 m2·g−1, an apparent density of 0.403–0.740 cm3·g−1 and a porosity of 60–78%. The actual cobalt content in the aerogels was 0.01–1.50 mmol per 1 g of SiO2, which could easily be tuned by the concentration of ethylenediamine moieties in the silica matrix. The introduction of cobalt(II) ions into the ethylenediamine-modified silica aerogel promoted the stability of the diamine moieties at the supercritical drying stage. The molecular prototype of the immobilized cobalt(II) complex, bearing one ethylenediamine ligand [Co(en)(MeCN)(NO3)2], was synthesized and structurally characterized. Using magnetometry in the DC mode, it was shown that cobalt(II)-modified silica aerogels exhibited slow magnetic relaxation in a nonzero field. A decrease in cobalt(II) concentration in aerogels from 1.5 mmol to 0.14 mmol per 1 g of SiO2 resulted in a weakening of inter-ion interactions; the magnetization reversal energy barrier likewise increased from 4 to 18 K.

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“…The functionalized paper, carbon nanostructures materials, semiconductor, water purification adsorbent, liquid crystal materials and the formaldehyde-free adhesive are literature applications for the cellulose-based products (Hosny et al , 1997; Vimala et al , 2009; Thakur et al , 2013; El-Saied et al , 2016; Canejo et al , 2017; Lotfy et al , 2018; Ravichandran et al , 2018; Basta et al , 2011, 2013, 2014, 2019; Ates et al , 2020). Additionally, there are medical and agriculture applications for the cellulose and its derivatives which are produced in form of hydrogel formulation (Lotfy and Basta, 2020; Lotfy et al , 2020; Hanna et al , 2020; Khalf-Alla et al , 2020; Basta et al , 2020, 2021a, 2021b, 2021c, 2021d, 2021e; Basta and Lotfy, 2021).…”

Section: Introductionmentioning

confidence: 99%

Selective route for enhancing liquid crystal-based hydroxylpropyl cellulose by esterification

Basta

Lotfy

Micky

et al. 2022

PRT

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Purpose This paper aims to study the effect of hydrolysis route of hydroxypropyl cellulose (HPC) on its esterification performance as liquid crystal material. The assessment was carried out from the data of spectra (Fourier-transform infrared analysis [FTIR] and 1H-nuclear magnetic resonance [1H-NMR]), thermal stability as well as optical properties via forming ordered mesophases at lower concentration than HPC. Design/methodology/approach The HPC was hydrolyzed by hydrochloric acid-methanol at times 9 and 18 h, and the products were esterified by decanoyl chloride. The products of hydrolysis and the esterification were characterized by FTIR, NMR, nonisothermal analysis, thermo-gravimetric analysis (TGA) and polarizing microscope to evaluate the role of degree of substitution of HPC as a result of hydrolysis, on esterification degree, thermal stability and thermal and liquid crystal behavior of the final esterified HPC. Findings The pretreatment by acid hydrolysis of HPC was successful for synthesizing novel cholesteric hydroxypropyl cellulose ester. The data of FTIR and TGA thermal analysis proved that hydrolysis and esterification of HPC with the decanoyl chain significantly enhanced crystallinity of this cellulose derivative from 0.57 to (1.7–1.9). Moreover, they provided products with superior thermal stability than pure HPC, as noticed from increasing the activation energy of degradation (Ea) from 514.3 to 806.2 kJ/mol. The NMR measurement proved that hydrolysis of HPC for 9 and 18 h decreased the degree of substitution from 3 to 2.1 and 1.3, respectively. Moreover, the esterified HPC showed a promising birefringence texture (chiral nematic) besides decreasing the critical concentration from 30% for HPC to 10% for the esterified unhydrolyzed HPC, while superior decreasing to 1–5% was observed for the esterified hydrolyzed HPC. Research limitations/implications There are two stages for preparation of decanoyl ester hydroxypropyl cellulose. At the first stage, HPC was treated by hydrochloric acid-methanol in ratio 1:10 at times 9 and18 h. At the second stage, HPC and hydrolyzed HPC were refluxed with decanoyl chloride (1:6) in presence of nitrogen atmosphere. The final product was precipitated by distilled water. Practical implications There are two stages for preparation of decanoyl ester hydroxypropyl cellulose. At the first stage, HPC was treated by hydrochloric acid-methanol in ratio 1:10 at times 9 and18 h. At the second stage, HPC and hydrolyzed HPC were refluxed with decanoyl chloride (1:6) in presence of nitrogen atmosphere. The final product was precipitated by distilled water. Originality/value The novelty of this work was focused on enhancing the crystallinity, thermal stability and liquid crystal behavior of esterified HPC, via decreasing the degree of substitution and consequently the type of OH group subjected to esterification. The decanoyl ester formation from the hydrolyzed hydroxypropyl cellulose is able to form ordered mesophases at even low concentration (promising birefringence texture at concentrations 1–5%). It is worthy to notice that the investigated route is able to omit the role of graphene oxide in promoting the liquid crystal behavior of HPC, as it hasn't any effect on critical concentration. This work will promote the use of HPC in technological applications, e.g. high modulus fibers and electronic devices.

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Synthesis, Characterization, Speciation, and Biological Studies on Metal Chelates of Carbohydrates with Molecular Docking Investigation

Cited by 15 publications

References 65 publications

The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Aerogel-Based Single-Ion Magnets: A Case Study of a Cobalt(II) Complex Immobilized in Silica

Selective route for enhancing liquid crystal-based hydroxylpropyl cellulose by esterification

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