Synthesis, characterization, structural-activity relationship and biomolecular interaction studies of heteroleptic Pd(II) complexes with acetyl pyridine scaffold

Patel, Nikita; Bhatt, Bhupesh S.; Vekariya, Pankajkumar A.; Vaidya, Foram U.; Pathak, Chandramani; Pandya, Juhi; Patel, Mohan N.

doi:10.1016/j.molstruc.2020.128802

Cited by 24 publications

(5 citation statements)

References 38 publications

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“…In ligands, L 1 and L 3 exhibit potent cytotoxicity activity than L 2 , L 4 L 5 and L 6 . LC 50 value of heterocyclic agents and Pd(II) complexes are observed range in range of 10.56-16.63 µg/mL, 5.70-7.58 µg/mL, respectively which is comparable to reported Pd(II) complexes (LC 50 = 5.68-7.94 µg/mL) [29]. The complexes exhibit good cytotoxicity activity than heterocyclic compounds.…”

Section: In Vivo Brine Shrimp Lethality Bioassaysupporting

confidence: 67%

“…According to previously reported literature, the absorption study of the complexes with bovine serum albumin is performed [29].…”

Section: Protein Binding Studies 2551 Absorption Titration Studymentioning

confidence: 99%

“…The molecules were formatted as PDB les and were allowed to interact with B-DNA in HEX 8.0 software on CORE i3 processor in windows 8.1 operating system. 2.5.5 Protein binding studies 2.5.5.1 Absorption titration study According to previously reported literature, the absorption study of the complexes with bovine serum albumin is performed [29].…”

Section: Molecular Docking Studymentioning

confidence: 99%

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Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Patel

Dhaduk

Dabhi

et al. 2021

Preprint

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A series of trisubstituted pyrazole-based ligands (L1-L6) and corresponding palladium(II) complexes were synthesized and characterized by conductivity measurement, 1H NMR, 13C NMR, Fourier Transform infrared (FT-IR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Synthesized compounds were screened for various biological activities. UV-Vis spectroscopy, viscosity measurement, fluorescence spectroscopy and molecular docking studies were used to determine the binding mode between HS-DNA and complexes, which suggest intercalation mode of binding. The protein binding study of complexes was evaluated by UV-visible spectroscopy. Antibacterial study of the complexes was screened against two Gram (+ve) and three Gram (-ve) bacteria and results show that all complexes are more effective against microorganisms than their respective ligands. The cytotoxicity of the synthesized compounds was tested against brine shrimp and MCF-7 Cells. The LC50 values of the ligand and complexes were found in the range of 9.24-4.12 µg/mL and 5.68-7.94 µg/mL, respectively.

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Section: In Vivo Brine Shrimp Lethality Bioassaysupporting

confidence: 67%

“…According to previously reported literature, the absorption study of the complexes with bovine serum albumin is performed [29].…”

Section: Protein Binding Studies 2551 Absorption Titration Studymentioning

confidence: 99%

Section: Molecular Docking Studymentioning

confidence: 99%

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Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Patel

Dhaduk

Dabhi

et al. 2021

Preprint

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“…[100] Palladium complexes 178-180 were recently reported as promising antimicrobial and anticancer agents. [101] They were active against specific bacteria among the tested strains but no compound was found with broad spectrum efficiency. Among the tested strains (S. aureus, B. subtilis, S. marcescens, P. aeruginosa, E. coli) compound 178 was potent against E. coli, 179 and 180 against P. subtilis.…”

Section: Coordination Compounds For Biological Applicationsmentioning

confidence: 98%

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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“…Benzimidazoles and their derivatives are well recognized for numerous properties like anti-tumor, anti-microbial, anti-viral, and anti-hypertensive. [27][28][29][30][31][32][33][34][35] Due to the structural similarity of the benzimidazole nucleus with natural compounds like vitamin-B12 derivatives and purine bases, the benzimidazole-based ligands are promising systems for the development of biologically active metal complexes. [32] Literature review suggests that benzimidazole-based platinum complexes and their cytotoxicity have been studied extensively to develop new antitumor drugs.…”

Section: Introductionmentioning

confidence: 99%

Aminobenzimidazole‐based (η⁶‐p‐cymene)ruthenium (II) complexes as nascent anticancer chemotherapeutics: Synthesis, crystal structure, DFT studies, HSA interactions, molecular docking, and cytotoxicity

Khan

AlFawaz

Farshori

et al. 2022

Applied Organom Chemis

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Two half‐sandwich organometallic ruthenium (II) complexes containing analogs of aminobenzimidazole of molecular formula [η6‐p‐cymene)Ru (LH)Cl2] 1 and [η6‐p‐cymene)Ru (LMe)Cl2] 2, where LH and LMe represent 2‐aminobenzimidazole and 2‐amino‐1‐methylbenzimidazole, respectively, have been synthesized and characterized by FT‐IR, NMR (1H, 13C), ESI‐MS, elemental analysis, and single X‐ray crystallography (for 1). Both complexes 1 and 2 were studied for human serum albumin (HSA) binding affinity using intrinsic, synchronous, three‐dimensional (3D) fluorescence, thermodynamics parameter, and Förster resonance energy transfer (FRET) analysis. The Stern–Volmer constant (KSV) values are of the order of ×105 M−1 and increases in KSV with temperature ascertained the static quenching. The molecular docking of both the complexes with HSA was carried out to ascertain the binding sites/pockets. Furthermore, compounds were evaluated for their cytotoxic potential against three human cancer cell lines, namely, HeLa, HepG2, MCF‐7, and non‐tumorigenic HEK293 cells. The IC50 value of 2 was found to <10 μM against Hela and HepG2 cancer cells and has better cytotoxic properties than cisplatin (a standard drug), yet showed minimal toxicity against HEK293 cells. These results suggest further investigation for the development of ruthenium complex 2 as potential anticancer therapeutics.

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Synthesis, characterization, structural-activity relationship and biomolecular interaction studies of heteroleptic Pd(II) complexes with acetyl pyridine scaffold

Cited by 24 publications

References 38 publications

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Aminobenzimidazole‐based (η⁶‐p‐cymene)ruthenium (II) complexes as nascent anticancer chemotherapeutics: Synthesis, crystal structure, DFT studies, HSA interactions, molecular docking, and cytotoxicity

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Synthesis, characterization, structural-activity relationship and biomolecular interaction studies of heteroleptic Pd(II) complexes with acetyl pyridine scaffold

Cited by 24 publications

References 38 publications

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Aminobenzimidazole‐based (η6‐p‐cymene)ruthenium (II) complexes as nascent anticancer chemotherapeutics: Synthesis, crystal structure, DFT studies, HSA interactions, molecular docking, and cytotoxicity

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Aminobenzimidazole‐based (η⁶‐p‐cymene)ruthenium (II) complexes as nascent anticancer chemotherapeutics: Synthesis, crystal structure, DFT studies, HSA interactions, molecular docking, and cytotoxicity