Synthesis, characterization, X-ray structure and DNA photocleavage by cis-dichloro bis(diimine) Co(III) complexes

Ghosh, Smita; Barve, Archika C.; Kumbhar, Avinash S.; Puranik, Vedavati G.; Datar, Prasanna A.; Sonawane, Uddhavesh B.; Joshi, Rajendra

doi:10.1016/j.jinorgbio.2005.11.022

Cited by 116 publications

(81 citation statements)

References 44 publications

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“…7 A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Table 2. The IC 50 values are comparable to the ones achieved from the best specific PAF receptor inhibitors like BN 52021 [59].…”

Section: Cytotoxicity Studiessupporting

confidence: 66%

“…The interesting observation from these data is that the initial complex [Re(CO) 5 Cl] with an IC 50 value of 170 ± 90 nΜ is better PAF inhibitor than both the phendione ligand and complex 1 with where coordination of a ligand to a metal ion enhances the inhibitory activity towards PAFaggregation of both the initial starting compounds -ligand and metallic moiety-e.g when organometallic moieties of Re coordinates to tamoxifen [60].…”

Section: Cytotoxicity Studiesmentioning

confidence: 99%

“…The data were plotted against the corresponding compound concentration in a semi-log chart and the IC 50 (the concentration causing 50% inhibition of cell proliferation) was determined from the dose-response curve, using GraphPad Prism 5.0. MTT assay was performed three independent times and in all experiments DMSO was lower than 1%.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Recently, molecular modelling studies of [Co(phendione) 2 Cl 2 ] + , shows that although it covalently binds to N7 of guanine, the ligand fits into the major groove without disrupting the helical structure of the B-DNA [50]. Thus, Fig.…”

Section: Circular Dichroism Experimentsmentioning

confidence: 99%

“…Actually, its biological activity is enhanced or reduced when it is coordinated to different metal centers [27,28] even if it keeps its planar geometry, indicating that the role of the metal moiety is crucial for the electronic properties both of the metal center and the phendione resulting in significant differences in biological activity. Recently, the anticancer activity of phendione and its Cu 2+ and Ag + complexes has been studied in a wide spectrum of cell lines, containing not only mouse's and monkeys' cells, but also human-derived cancer cell lines [23,24,26].…”

Section: Introductionmentioning

confidence: 99%

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Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

Kaplanis

Stamatakis

Papakonstantinou

et al. 2014

Journal of Inorganic Biochemistry

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The complex fac-[Re(CO) 3 (phendione)Cl] (1) (where phendione=1,10-phenanthroline-5,6-dione) has been synthesized and fully characterized by UV-visible, FTIR, and NMR techniques.The DNA binding properties of 1 are investigated by UV-spectrophotometric (melting curves), covalent binding assay, CV (cyclic voltammetry), circular dichroism (CD) and viscosity measurements. Experimental data indicate that 1 fits into the major groove without disrupting the helical structure of the B-DNA in contrast to the free phendione which intercalates within the base pairs of DNA. Upon irradiation, complex 1 promotes the cleavage of plasmid pBR322 DNA from supercoiled form I to nicked form II via a proton coupled electron transfer mechanism. This comes as a result of experimental data in anaerobic /aerobic conditions and in the presence of DMSO. The biological activities of 1 and its precursors [Re(CO) 5 Cl] and phendione are tested towards a series of cancerous cell lines as glioblastoma (T98G), prostate cancer (PC3) and breast cancer (MCF-7) as well as platelet activating factor (PAF)-aggregation. Moreover, all the aforementioned compounds are tested for their ability to modulate PAF-basic metabolic enzymes activities in preparations of rabbit leukolytes. The in vitro experiments indicate that phendione has a better antitumor effect than cisplatin whereas [Re(CO) 5 Cl] is a better PAF inhibitor than both the phendione ligand and 1.Moreover, for the first time it is indicated that [Re(CO) 5 Cl], with a IC 50 of 17 nM is comparable to the widely used PAF receptor antagonists, BN52021 and WEB2170 with IC 50 of 30 and 20 nM, respectively, whereas 1 affects PAF-catabolism.

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“…7 A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Table 2. The IC 50 values are comparable to the ones achieved from the best specific PAF receptor inhibitors like BN 52021 [59].…”

Section: Cytotoxicity Studiessupporting

confidence: 66%

Section: Cytotoxicity Studiesmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Circular Dichroism Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

Kaplanis

Stamatakis

Papakonstantinou

et al. 2014

Journal of Inorganic Biochemistry

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Photoactivated DNA Cleavage and Anticancer Activity of 3d Metal Complexes

Chakravarty

Roy

2011

Progress in Inorganic Chemistry

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Target Delivery of a Novel Antitumor Organoplatinum(IV)‐Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo

et al. 2016

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An inactive organoplatinum(IV)-substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of Pt(IV) -PW11 with DSPE-PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such Pt(IV) -PW11 -DSPE-PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.

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Synthesis, characterization, X-ray structure and DNA photocleavage by cis-dichloro bis(diimine) Co(III) complexes

Cited by 116 publications

References 44 publications

Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

Photoactivated DNA Cleavage and Anticancer Activity of 3d Metal Complexes

Target Delivery of a Novel Antitumor Organoplatinum(IV)‐Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo

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