Synthesis, characterization, X-ray structure and in vitro antimycobacterial and antitumoral activities of Ru(II) phosphine/diimine complexes containing the “SpymMe2” ligand, SpymMe2=4,6-dimethyl-2-mercaptopyrimidine

Ruthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosis

“…Specifically, Ru(II) complexes have shown excellent activity against in vitro MTB, being up to 150 times more active than their free ligands 4,6-dimethyl-2-mercaptopyrimidine; 1,4 bis(diphenylphosphino)butane; 1,2-bis(diphenylphosphio)ethane, bis(diphenylphosphino) methane, triphenylphosphine, 2,2 0 -bipyridine, 4,4 0 -dimethyl-2,2 0 -bipyridine, 2-pyridinecarboxylic acid and, interestingly, in these complexes the activity was higher, when they contained three chelated ligands, than that of the precursor complexes containing two chelated and two chloride ligands [9,14].…”

GENES DIFFERENTIALLY EXPRESSED BY Mycobacterium tuberculosis AFTER EXPOSURE TO RUTHENIUM PHOSPHINIC COMPOUND AND ISONIAZID

“…Ruthenium complexes, including organometallic compounds containing phosphine ligands such as picolinic acid, have shown to be active against M. tuberculosis [8][9][10][11] and a number of other bacteria [12]. Nascimento et al [9] and Pavan et al [10,11] synthesized ruthenium complexes containing phosphines, diimines and picolinic acid such as ligands.…”

“…Nascimento et al [9] and Pavan et al [10,11] synthesized ruthenium complexes containing phosphines, diimines and picolinic acid such as ligands. These complexes' library received the acronym "SCAR" and their anti-M. tuberculosis activity, cytotoxicity and intracellular activities were investigated [9][10][11].…”

“…Nascimento et al [9] and Pavan et al [10,11] synthesized ruthenium complexes containing phosphines, diimines and picolinic acid such as ligands. These complexes' library received the acronym "SCAR" and their anti-M. tuberculosis activity, cytotoxicity and intracellular activities were investigated [9][10][11]. In these cases the Minimal Inhibitory Concentration (MIC) of compounds were comparable to or better than MICs of first and second line anti-TB drugs and even 100 times more active than their free ligands [9][10][11].…”

Correlation of [RuCl3(dppb)(VPy)] Cytotoxicity with its Effects on the Cell Membranes: An Investigation Using Langmuir Monolayers as Membrane Models

“…18,19 Phosphine complexes of various transition metals (Au, Ag, Cu, Ru, Rh, Pt, Pd) have been evaluated as potential antitumor agents in various human tumor cell lines. 20−25 For Au complexes, for instance, activity has been attributed to the presence of the phosphine ligands, since similar complexes without them had a very low activity.…”