Synthesis, characterizations, and biocompatibility evaluation of polycaprolactone–MXene electrospun fibers

Awasthi, Ganesh Prasad; Maharjan, Bikendra; Shrestha, Sita; Bhattarai, Deval Prasad; Yoon, Deockhee; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.colsurfa.2019.124282

Cited by 90 publications

(35 citation statements)

References 54 publications

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“…MXene nanosheets occupy most of the space, which is very good for electron transport. The chemical composition derived from EDS is consistent with articles by other authors [8,29]. The most intensive signal (~74%) is from the C-Kα line since both PCL and Ti 3 C 2 contains it.…”

Section: Resultssupporting

confidence: 88%

Investigation of AC Electrical Properties of MXene-PCL Nanocomposites for Application in Small and Medium Power Generation

et al. 2021

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The paper examined Ti3C2Tx MXene (T—OH, Cl or F), which is prepared by etching a layered ternary carbide Ti3AlC2 (312 MAX-phase) precursor and deposited on a polycaprolactone (PCL) electrospun membrane (MXene-PCL nanocomposite). X-ray Diffraction analysis (XRD) and Scanning Electron Microscopy (SEM) indicates that the obtained material is pure Ti3C2 MXene. SEM of the PCL-MXene composite demonstrate random Ti3C2 distribution over the nanoporous membrane. Results of capacitance, inductance, and phase shift angle studies of the MXene-PCL nanocomposite are presented. It was found that the frequency dependence of the capacitance exhibited a clear sharp minima in the frequency range of 50 Hz to over 104 Hz. The frequency dependence of the inductance shows sharp maxima, the position of which exactly coincides with the position of the minima for the capacitance, which indicates the occurrence of parallel resonances. Current conduction occurs by electron tunneling between nanoparticles. In the frequency range from about 104 Hz to about 105 Hz, there is a broad minimum on the inductance relationship. The position of this minimum coincides exactly with the position of the maximum of the phase shift angle—its amplitude is close to 90°. The real value of the inductance of the nanocomposite layer was determined to be about 1 H. It was found that the average value of the distance over which the electron tunnels was determined with some approximation to be about 5.7 nm and the expected value of the relaxation time to be τM ≈ 3 × 10−5 s.

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Section: Resultssupporting

confidence: 88%

Investigation of AC Electrical Properties of MXene-PCL Nanocomposites for Application in Small and Medium Power Generation

et al. 2021

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“…MXene (Ti 3 C 2 T X ) exhibits superior biocompatibility and antibacterial efficiency against both Gram-negative and Gram-positive bacteria than graphene oxide due to its ultrathin structure and unique physiochemical properties 19 , 20 . Awasthi et al found that the addition of MXene into PCL nanofibers maintained good biocompatibility in vitro with ibroblasts (NIH-3T3) and preosteoblasts (MC3T3-E1) cell lines 21 . In addition, the presence of Ti 3 C 2 T X nanosheets contributed to reducing the diameter and improving the morphology of PCL/Ti 3 C 2 T X nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing

Zeng

Cheng

Liang

et al. 2022

Sci Rep

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Due to the rise in bacterial resistance, the antibacterial extractions from Chinese herbs have been used more frequently for wound care. In this work, baicalin, an extraction from the Chinese herb Scutellaria baicalensis, was utilized as the antibacterial component in the poly(ε-caprolactone)/MXene (PCL/Ti3C2TX) hybrid nanofibrous membranes for wound dressing. The results revealed that the presence of Ti3C2TX aided in the diameter reduction of the electrospun nanofibers. The PCL hybrid membrane containing 3 wt% Ti3C2TX nanoflakes and 5 wt% baicalin exhibited the smallest mean diameter of 210 nm. Meanwhile, the antibacterial tests demonstrated that the PCL ternary hybrid nanofibers containing Ti3C2TX and baicalin exhibited adequate antibacterial activity against the Gram-positive bacterial S. aureus due to the good synergistic effects of Ti3C2TX naoflakes and baicalin. The addition of Ti3C2TX nanoflakes and baicalin could significantly improve the hydrophilicity of the membranes, resulting in the release of baicalin from the nanofibers. In addition, the cytotoxicity of the nanofibers on rat skeletal myoblast L6 cells confirmed their good compatibility with these PCL-based nanofibrous membrances. This work offers a feasible way to prepare antibacterial nanofibrous membranes using Chinese herb extraction for wound dressing applications.

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“…6). 72 However, additional studies are warranted for the systematic analysis and functionalization of these materials for broadening their applications, especially in the field of tissue engineering and regenerative medicine.…”

Section: Ti 3 C 2 Mxenesmentioning

confidence: 99%

MXenes and MXene-based materials for tissue engineering and regenerative medicine: recent advances

2021

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Synthesis, characterizations, and biocompatibility evaluation of polycaprolactone–MXene electrospun fibers

Cited by 90 publications

References 54 publications

Investigation of AC Electrical Properties of MXene-PCL Nanocomposites for Application in Small and Medium Power Generation

Investigation of AC Electrical Properties of MXene-PCL Nanocomposites for Application in Small and Medium Power Generation

Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing

MXenes and MXene-based materials for tissue engineering and regenerative medicine: recent advances

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