Synthesis, Crystal Structure and Antimicrobial Activity of a Linear Trinuclear Nickel(II) Complex with Schiff Base Ligand

Abstract

A new linear trinuclear Schiff base nickel(II) complex, [Ni{NiL(μ 2 -η 1 :η 1 -OAc)(OH 2 )} 2 ]·H 2 O, where L is the dianionic form of N,N'-bis(5-chloro-2-hydroxybenzylidene)-1,3-propanediamine (H 2 L), was synthesized and characterized by elemental analyses, IR spectroscopy, and X-ray single-crystal determination. There are three bridges across the Ni-Ni atom pairs, involving two phenolate O atoms of a Schiff base ligand, and an O-C-O moiety of a μ 2 -η 1 :η 1 -OAc group. The Ni atoms have octahedral coordination. The acetate bridges linking the central and terminal nickel atoms are mutually trans. The adjacent Ni•••Ni distances are 3.047(1) Å. The complex was evaluated for its antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method.

Anion Induced Synthesis, Structural Characterization and Antibacterial Activity of Zinc(II) Complexes Derived from 5-Bromo-2-((2-(diethylamino)ethylimino)methyl) phenol

“…All the complexes have better activities on Staphylococcus aureus and Escherichia coli than the zinc complexes with the ligands 4-methoxybenzoic acid (1-pyridin-2-ylmethylidene) hydrazide and benzoic acid (1-pyridin-2-ylethylidene)hydrazide, 19 the oxovanadium complexes derived from N'-(3-bromo-2-hydroxybenzylidene)picolinohydrazide and 2-chloro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide, 20 the cobalt, zinc and cadmium complexes derived from 2-hydroxy-N'-(pyridin-2-ylmethylene)benzohydrazide, 21 and the nickel complex with the ligand N,N'-bis(5-chloro-2-hydroxybenzylidene)-1,3-propanediamine. 22 Complexes 1 and 3 have better activities on and 2, 4-difluoro-6-((3-morpholinopropylimino)methyl)phenolate, 23 and similar activities with the copper complex derived from 2-hydroxy-5-methylbenzaldehyde oxime. 24 Notably, complexes 1 and 3 have similar activity against Staphylococcus aureus, and complex 3 has similar activity against Escherichia coli when compared with Tetracycline.…”