Synthesis, Crystal Structure, and Antimicrobial Activity of a Novel Trinuclear Cadmium(II) Complex Derived From 2-Ethoxysalicylaldehydethiosemicarbazone

Xue, Ling-Wei; Wang, Xiang; Zhao, Gan-Qing

doi:10.1080/15533174.2012.680139

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…The ethoxy derivative of salal thiosemicarbazone ligand was synthesized following a published procedure. 5 The metal precursors, [RuHCl(CO)(py)(PPh3)2], [RuHCl(CO)AsPh3)3] and [RuHCl(CO)(PPh3)3], were synthesized by reported procedure. [6][7][8] In a Vario EL III CHNS analyzer, microanalysis (elemental analysis) of the samples were performed.…”

Section: Methodsmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

Sampath¹,

Ashokkumar²,

Venkatachalam³

et al. 2019

RJC

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A set of complexes, [RuCl(CO)(B)(EPh3)L] (where E=P/As; B=PPh3/AsPh3/py; L = ligand), of ruthenium have been synthesized by solution method. The structure of the ruthenium(II) complexes were determined by microanalytical techniques and spectral techniques (CHNS, Infrared, ultraviolet-visible and NMR spectroscopic techniques). FT-IR results reveal that thiosemicarbazone is coordinated to Ru(II)via ONS. In addition, the structure of the compounds, thiosemicarbazone ligand and complexes, was confirmed by Nuclear Magnetic Resonance Spectroscopy. Further, the synthesized ligand and its complexes were analyzed against human pathogens.

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Section: Methodsmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

Sampath¹,

Ashokkumar²,

Venkatachalam³

et al. 2019

RJC

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“…[9][10][11] Mainly, condensation products of 3-ethoxysalicylaldehyde were effective cytotoxic ligands on HepG2, HCT116, and MCF-7 cells. 12 In addition, antimicrobial effects of 3-ethoxysalicylaldehyde [13][14][15] and 2-amino-4chlorophenol-derived Schiff bases are reported. 16,17 Therefore in this study, it was found worthy of investigating the anticancer activity of a Schiff base, (E)-4chloro-2-((3-ethoxy-2-hydroxybenzylidene)amino)phenol (ACES), which is a condensation product of 2-amino-4-chlorophenol with 3-ethoxysalicylaldehyde.…”

Section: Introductionmentioning

confidence: 99%

P38-β/SAPK-inhibiting and apoptosis-inducing activities of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene) amino)phenol

Karaosmanoğlu

2020

Hum Exp Toxicol

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The present study has three purposes; first evaluating cytotoxicity of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene)amino)phenol (ACES), second deciphering ACES-mediated cellular death mechanism, and third estimating ACES-mediated alterations in the expressions of mitogen-activated protein kinase (MAPK) pathway-related genes. Neutral red uptake assay, cell cycle analysis, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) measurements, caspase 3/7 and 9 activations, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were implemented. IC50 values of ACES-treated five cells were around 4–6 µg/mL. However, Caco-2 and Huh-7 cells were found to be twofold resistant and fivefold sensitive with IC50 values of 11 µg/mL and 0.93 µg/mL, respectively. In this study, it was initially reported that ACES exhibits selective cytotoxicity to Huh-7 cells. In addition, ACES induced apoptosis by nuclear fragmentation, MMP disruption, and intracellular ROS elevation in MCF-7 cells. qRT-PCR experiment indicated the expressions of 30 genes including ATF2, CREB1, MYC, NFATC4 (NFAT3), CCNA1, CCNB1, CCND2, CDK2, CDKN1A (p21CIP1), CDKN1C (p57KIP2), CDKN2A (p16INK4a), CDKN2B (p15INK4b), DLK1, NRAS, CDC42, PAK1, MAP4K1 (HPK1), MAP3K3 (MEKK3), MAP2K3 (MEK3), MAP2K6 (MEK6), MOS, MAPK1 (ERK2), MAPK8 (JNK1), MAPK10 (JNK3), MAPK11 (p38-β), LAMTOR3 (MP1), MAPK8IP2 (JIP-1), PRDX6 (AOP2), COL1A1, and HSPA5 (Grp78) were downregulated at least 1.5-fold. Moreover, ACES effectively inhibited expressions of genes that code for elements of p38-β/stress-activated protein kinase (SAPK) pathway. ACES has the potential to be used for the reversal of trastuzumab resistance in breast cancer patients by inhibiting p38/SAPK pathway in MCF-7 cells. Therefore, with the selective cytotoxic, apoptosis-inducing, and p38-β/SAPK-inhibiting activities, ACES can be utilized for developing a novel anticancer drug.

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Synthesis, Characterization, Antibacterial, DNA Binding and Cleavage Studies of Mixed Ligand Cu(II), Co(II) Complexes

et al. 2014

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Mixed-ligand Cu(II), Co(II) complexes of formulae [Co(NSALT)(A.A)(H2O)](1), [Co(OHAPT)(A.A)H2O](2), and [Cu(ESALT)(ABPH)H2O] (3) were obtained by refluxing methanol solutions of copper, cobalt chlorides with the appropriate ligands. The complexes were characterized by the ESI-MASS, vibrational spectroscopy (Fourier transform-IR), (1)H-NMR spectroscopy, UV-vis spectroscopy, TGA, ESR, SEM and powder XRD. The preliminary DNA-binding activity of the complexes was studied by recording electronic absorption spectra of the complexes in presence of CT-DNA. The binding constants of three complexes towards calf thymus DNA (CT-DNA) [1.2 × 10(4) M(-1) for 1, 2.5 × 10(4) M(-1) for 2, and 3.0 × 10(4) M(-1) for 3] indicate strong interaction of 3. Changes in the fluorescence of ethidium bromide in the presence of DNA suggest intercalation into or electrostatic interactions with CT DNA. The quenching constants, KSV towards-DNA calculated through fluorescence spectra are 2.9 × 10(4) M(-1)for 1, 1.8 × 10(4) M(-1) for 2, and 3.2 × 10(4) M(-1) for 3. Docking studies on DNA complexes confirm the binding of 1 and 2 in the major groove of CT-DNA (CTP-1 Endonuclease). Moreover, the antibacterial effect of 1-3 against the five bacterial species was evaluated. The metal complexes have cleavage affinity towards PBR322 plasmid. Furthermore, the antioxidant activities of the complexes were determined by DPPH scavenging activity method.

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Synthesis, Crystal Structure, and Antimicrobial Activity of a Novel Trinuclear Cadmium(II) Complex Derived From 2-Ethoxysalicylaldehydethiosemicarbazone

Cited by 5 publications

References 20 publications

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

P38-β/SAPK-inhibiting and apoptosis-inducing activities of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene) amino)phenol

Synthesis, Characterization, Antibacterial, DNA Binding and Cleavage Studies of Mixed Ligand Cu(II), Co(II) Complexes

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