Synthesis, crystal structure and antiproliferative evaluation of some new substituted benzothiazoles and styrylbenzothiazoles

Synthesis and Antitumor Evaluation of Novel Derivatives of 6-Amino-2-phenylbenzothiazoles

“…In connection with our studies on the synthesis and biological properties of substituted benzothiazoles [6][7][8] we turned our attention to the synthesis and antitumor evaluation of novel 2-(substituted-phenyl)-6-aminobenzothiazole as analogous of 2-(4-aminophenyl)benzothiazole prepared as hydrochloride or dihydrochloride salts.…”

Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents

“…In the past decades, 2-aminobenzothiazole and its derivatives have received much attention due to their chemotherapeutic value in the development of novel anthelmintics and antimicrobial agents [8−12]. In addition, many 2-aminobenzothiazole derivatives exhibit a wide variety of biological activities such as diuretic [13], anticancer [14], anticonvulsant [15,16], antihistamine [17] and anti-inflammatory [18]. Moreover, the thiazole ring is an important building block in medicinal chemistry and endowed with antimicrobial, anthelmintic and various other pharmacological activities [19−21].…”

Synthesis of Some New Biologically Active Benzothiazole Derivatives Containing Benzimidazole and Imidazoline Moieties

“…Benzothiazole derivatives have been studied extensively and found to have diverse chemical reactivity and broad spectrum of biological activity such as antitumor agents, [1][2][3] antimicrobial, [4][5][6] analgesics, 7 anti-inflammatory, [7][8][9] anti HIV, 10 antileishmanial, 11 etc. Further a wide range of therapeutic activities of benzimidazole show that they are also anticancer, 12 antihypertension, 13 antioxidant, 14 antiviral, 15 proton pump blocker, 16 antinociceptive, 17 anti-inflammatory, 17,18 analgesic, 18 antiparasites, 19 human cytomegalovirus (HCMV) replication inhibitor, 20 fungicidal, 21 antihistamines, 22,23 etc.…”