Synthesis, Crystal Structure and Antitumor Activity of Novel 2-Cyano-N-(quinolin-3-yl)acetamide

Abstract

Recently considerable attention has been devoted to the synthesis of new derivatives of quinoline on the account of their reported biological activities 1-8. From the literature survey, several methods have been described for the elaboration of substituted quinolines 9-11 , which as a class have been reported to have anticancer and antileukemic activity. Different mechanisms account for the cytotoxic effect of this class of compounds, the most prominent mechanism was the inhibition of carbonic anhydrase isozymes. Cancer is a top killer of human beings, thus great urgency to develop highly efficacious and minimally toxic treatments for cancer. Although tremendous progress has been achieved in the development of novel cancer treatments, most of the current cancer drugs usually exhibit high toxicity and are severely resisted by tumor cells in the clinic. This dilemma is particularly true for DNA-damaging agents, the mainstay of cancer treatment 12. Quinolines were found to possess several pharmacological properties, including anticancer activity 13-17. It was also found that the acetamide derivatives constitute an important class of drug, with several types of pharmacological agents possessing anticancer activity 18-21 among others. A large number of structurally novel quinolines have ultimately been reported to show substantial anticancer activity in vitro and in vivo 22. Several mechanisms have been reported for anticancer activity of the quinoline sulfonamide compounds and the most prominent of these