Synthesis, crystal structure, and nuclease activity of planar mono-heterocyclic base copper(II) complexes

Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage

“…Further, on treating [Cu(dpq) 2 ] 2+ with ascorbic acid a diamagnetic blue species of [Cu(dpq) 2 ] + was instantaneously precipitated [47]. On the other hand, treatment of [Cu(dpq) ( 2+ complexes bind at the minor groove of B-DNA and generates freely diffusible hydroxyl radical, which abstracts C1 hydrogen [72]. As hydroxyl radicals are found to be not involved in the cleavage, the possibility of formation of [Cu(diimine)] + is ruled out.…”

Synthesis and the characterization of Schiff-base copper complexes: Reactivity with DNA, 4-NPP and BNPP

“…Varying the ligands could tune the reactivity of the complex towards DNA. Planar ligands with pi systems have been noted to be good intercalators [54][55][56][57][58]. The planarity of such ligands contributes to the intercalating mode of binding of the complex to DNA.…”

Synthesis, structural characterization and cytotoxic activity of ternary copper(II)–dipeptide–phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer

“…There is large amount of evidence supporting its DNA noncovalent binding to the minor groove of the double stranded DNA, cleaving DNA at its binding region [7,8]. [Cu(phen) 2 ] 2+ also intercalates in the minor groove of DNA, and shows nuclease activity [9,10]. In addition, a number of heteroleptic phen-containing Cu(II) complexes show DNA binding and nuclease activity, thus preventing cellular growth [2,3].…”