Synthesis, crystal structure, DNA binding, and cleavage activity of butterfly-like 12-coordinate praseodymium(III) complex

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

show abstract

Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

Nagamani¹,

Reddy

Srinivasulu

et al. 2021

Orient. J. Chem

View full text Add to dashboard Cite

show abstract

Synthesis, Spectral Characterization and Antibacterial Activity of Copper(II) Complexes of Functionalized Hydrazones

2019

View full text Add to dashboard Cite

Copper(II) complexes having the formula CuL2 {where, L = 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH)} have been investigated on the basis of elemental analysis, molar conductivity measurements, magnetic susceptibility, UV-visible, IR and ESR spectral data. Non-electrolytic nature of the complexes are revealed by molar conductance data. IR spectral data suggested that hydrazones act as tridentate ligands. The spin Hamiltonian, orbital reduction and bonding parameters of complexes are calculated using ESR spectra of complexes. The compounds are screened for their antibacterial activities against Pseudomonas aureoginos and Bacillus cereus. Acetoylhydrazones show more antibacterial activity than the corresponding benzoyl hydrazones. Some of the Cu(II) complexes show more activity than hydrazone ligands.

show abstract

Synthesis, Structural Characterization and DNA Binding Studies on Transition Metal Complexes with 2-Formylpyridine Benzoylhydrazone

et al. 2019

View full text Add to dashboard Cite

The hydrazone ligand, 2-formylpyridine benzoylhydrazone (FPBH) has been used to synthesize copper(II), nickel(II) and cobalt(II) complexes and characterized by elemental analyses, mass spectra, molar conductivity data IR, UV-visible spectroscopy. The complexes are found to have general formula M(FPBH)2 (where, M = Cu(II), Ni(II) and Co(II). Further the copper complex is investigated using ESR spectra. The spin Hamiltonian, orbital reduction and bonding parameters are calculated for the complex. The complex, Ni(FPBH)2 is structurally characterized based on single crystal X-ray crystallography. The complex crystallizes in monoclinic space group P21/c with a = 11.2632(2) Å, b = 8.8958(2) Å, c = 23.0834(5) Å, α = 90°, β = 90.858(2)°, γ = 90°, V = 2312.59(8) Å3 and Z = 4 with central Ni(II) ion in distorted octahedral structure coordinated by two tridentate FPBH ligand. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. The copper complex binds more strongly than either nickel or cobalt complexes.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis, crystal structure, DNA binding, and cleavage activity of butterfly-like 12-coordinate praseodymium(III) complex

Cited by 4 publications

References 38 publications

Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

Synthesis, Spectral Characterization and Antibacterial Activity of Copper(II) Complexes of Functionalized Hydrazones

Synthesis, Structural Characterization and DNA Binding Studies on Transition Metal Complexes with 2-Formylpyridine Benzoylhydrazone

Contact Info

Product

Resources

About