Synthesis, crystal structure, DNA interaction and cleavage activities of mononuclear and trinuclear copper(II) complexes

Haribabu, P; Patil, Yogesh P.; Reddy, K. Hussain; Nethaji, Munirathinam

doi:10.1007/s11243-013-9786-5

Cited by 13 publications

(6 citation statements)

References 44 publications

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“…Among these, polynuclear copper(II) species [4][5][6][7][8] are the most intriguing and investigated ones due to their plain structural properties, ability to mimic active sites in certain copper containing proteins and easy to rationalize and diverse magnetic properties as the simplest examples of magnetic exchange interactions. [9][10][11][12][13][14] From another standpoint, the selection or design of the organic ligands are of cruical importance on self-assembly of metal ions owing to their requisite functional roles as transmitters of close metalmetal communications other than they are the backbones of these polynuclear aggregates.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and DFT-Based Investigation of a Novel Trinuclear Singly-Chloro-Bridged Copper(II)-1-Vinylimidazole Complex

Yolcu

Demir

Andaç

et al. 2016

ACSi

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A novel trinuclear copper(II) complex [Cu 3 (μ-Cl) 2 Cl 4 (1-Vim) 6 ] with monodentate 1-vinylimidazole (1-Vim) and chloro ligands has been prepared and experimentally characterized by elemental analysis, thermogravimetry (TGA, DTG, DTA), X-ray single crystal diffractometry, TOF-MS and FT-IR spectroscopies. The electronic and structural properties of the complex were further investigated by DFT/TD-DFT methods. Density functional hybrid method (B3LYP) was applied throughout the calculations. The calculated UV-Vis results based on TD-DFT approach were simulated and compared with experimental spectrum. Based on the data obtained, DFT calculations have been found in reasonable accordance with experimental data.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and DFT-Based Investigation of a Novel Trinuclear Singly-Chloro-Bridged Copper(II)-1-Vinylimidazole Complex

Yolcu

Demir

Andaç

et al. 2016

ACSi

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“…In the light of the above and in continuation of earlier work [28,29] on DNA binding and cleavage activities of transition metal complex, herein we report synthesis, spectral characterization and DNA binding properties of lanthanide(III) complexes of 2-acetylpyridine isonicotinoylhydrazone for the first time.…”

Section: Introductionmentioning

confidence: 78%

Spectral characterization and DNA binding properties of lanthanide(III) complexes with 2-acetylpyridine isonicotinoylhydrazone (APINH)

Moksharagni¹,

Reddy²

2016

Bull. Chem. Soc. Eth.

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ABSTRACT. The lanthanide(III) complexes of general formula of [Ln(APINH)2(NO3](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; APINH = 2-acetylpyridine isonicotinoyl hydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that APINH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridinenitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is suggested.

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“…The values of K b for the complexes follow the order 5 [ 3 [ 4 [ 2 [ 1, suggesting that the dinuclear complexes bind DNA more strongly than the mononuclear complex. This is probably due to the strong supramolecular (non-covalent) interactions between these cationic complexes and the negatively charged phosphodiester backbone of DNA [17,34]. In the absence of intercalation, we expect groove binding via hydrophobic interactions involving the phenyl groups of the complex and/or electrostatic interactions between the DNA and complex.…”

Section: Electronic Absorption Titrationsmentioning

confidence: 99%

“…The cleavage mechanism is strongly influenced by the metal bound to the phen ligand; complexes of copper(II) or iron(II) can both give oxidative cleavage of the DNA [14]. As a part of our ongoing research programme [15][16][17] concerning DNA-binding and cleavage activities of dinuclear transition metal complexes, herein we report the synthesis, characterization and nuclease activity of four di-copper phenanthroline complexes bridged by different anions.…”

Section: Introductionmentioning

confidence: 99%

DNA-binding and nuclease activity of 1,10-phenanthroline-based thiocyanato, acetato, azido and benzoato bridged dinuclear copper(II) complexes

Pagonda

Patil

Reddy

et al. 2011

Transition Met Chem

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The mononuclear Cu(II) complex [Cu(phen)-(H 2 O)(NO 3 ) 2 ] (1), obtained by the reaction of 1,10-phenanthroline with Cu(NO 3 ) 2 Á3H 2 O in methanol solution, reacts with anionic ligands SCN -, AcO -, N 3 -and PhCO 2 -in MeOH solution to form the stable binuclear complexes [Cu 2. The molecular structure of complex 3 was determined by single-crystal X-ray diffraction studies. These complexes were characterized by electronic, IR, ESR, magnetic moments and conductivity measurements. The electrochemical behaviour of the complexes was investigated by cyclic voltammetry. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. Their DNA cleavage activity was studied on doublestranded pBR322 plasmid DNA using gel electrophoresis experiments in the absence and presence of H 2 O 2 as oxidant.

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Synthesis, crystal structure, DNA interaction and cleavage activities of mononuclear and trinuclear copper(II) complexes

Cited by 13 publications

References 44 publications

Synthesis, Characterization and DFT-Based Investigation of a Novel Trinuclear Singly-Chloro-Bridged Copper(II)-1-Vinylimidazole Complex

Synthesis, Characterization and DFT-Based Investigation of a Novel Trinuclear Singly-Chloro-Bridged Copper(II)-1-Vinylimidazole Complex

Spectral characterization and DNA binding properties of lanthanide(III) complexes with 2-acetylpyridine isonicotinoylhydrazone (APINH)

DNA-binding and nuclease activity of 1,10-phenanthroline-based thiocyanato, acetato, azido and benzoato bridged dinuclear copper(II) complexes

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