Synthesis, crystal structures, and anti-convulsant activities of ternary [ZnII(3,5-diisopropylsalicylate)2], [ZnII(salicylate)2] and [ZnII(aspirinate)2] complexes

Lemoine, Pascale; Viossat, Β.; Dung, Nguyen Huy; Tomas, Α.; Morgant, Georges; Greenaway, Frederick T.; Sorenson, John R. J.

doi:10.1016/j.jinorgbio.2004.07.010

Cited by 64 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For related literature, see: He et al (2005He et al ( , 2006; Lemoine et al (2004); Thurston et al (2004); Valigura et al (2004); Wang & Okabe (2004); Wen et al (2007); Zhu et al (2003).…”

Section: Related Literaturementioning

confidence: 99%

(2,2′-Bipyridine-κ²N,N′)(3,5-dinitrosalicylato-κ²O¹,O²)(pyridine-κN)copper(II)

et al. 2007

View full text Add to dashboard Cite

Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.008 Å; R factor = 0.052; wR factor = 0.149; data-to-parameter ratio = 12.1.In the title compound, [Cu(C 7 H 2 N 2 O 7 )(C 5 H 5 N)(C 10 H 8 N 2 )], the Cu II atom is coordinated by two O atoms from a 3,5dinitrosalicylate ligand, two N atoms from a 2,2 0 -bipyridine ligand and one N atom from a pyridine ligand in a squarepyramidal geometry. The structure is stabilized by C-HÁ Á ÁO hydrogen bonds andinteractions between the bipyridine ligands, with a centroid-centroid distance between neighbouring aromatic rings of 3.96 (8) Å . 2 )] M r = 524.93 Triclinic, P1 a = 9.981 (2) Å b = 10.269 (2) Å c = 11.913 (2) Å = 68.99 (3) = 67.88 (3) = 79.08 (3) V = 1053.9 (5) Å 3 Z = 2 Mo K radiation = 1.10 mm À1 T = 293 (2) K 0.24 Â 0.23 Â 0.21 mm Data collection Rigaku R-AXIS RAPID IP diffractometer Absorption correction: multi-scan (ABSCOR; Higashi, 1995) T min = 0.767, T max = 0.797 8700 measured reflections 3813 independent reflections 3149 reflections with I > 2(I) R int = 0.052

show abstract

“…For related literature, see: He et al (2005He et al ( , 2006; Lemoine et al (2004); Thurston et al (2004); Valigura et al (2004); Wang & Okabe (2004); Wen et al (2007); Zhu et al (2003).…”

Section: Related Literaturementioning

confidence: 99%

(2,2′-Bipyridine-κ²N,N′)(3,5-dinitrosalicylato-κ²O¹,O²)(pyridine-κN)copper(II)

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Mn(II) complexes show anticancer/antiproliferative activities. Zn(II) complexes are utilized for the treatment of Alzheimer's disease, and can act as radio‐protective agents, tumor photosensitizers, anticonvulsants, antidiabetic insulin mimetics and anti‐inflammatories and show cytotoxicity against human cancer cell lines . Some Zn(II) complexes can strongly bind to and cleave DNA, they exhibit prominent anticancer activities and they regulate apoptosis .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, apoptosis and molecular docking of three Mn(II), Zn(II) and Cu(II) complexes with terpyridine‐based carboxylic acid

Gao

Feng

et al. 2017

Applied Organom Chemis

View full text Add to dashboard Cite

A series of novel cytotoxic compounds, [Mn(cpt)2], [Zn(tpt)(H2O)2]⋅DMA⋅2(H2O) and [Cu(tpt)]⋅DMA (cpt = 4′‐(4‐carboxyphenyl)‐2,2′:6′,2″‐terpyridine, tpt = 4‐(2,4,6‐tricarboxylphenyl)‐2,2′:6′,2″‐terpyridine, DMA = (CH3)2NH), were isolated and characterized. The structures of these complexes were characterized using single‐crystal X‐ray diffraction. The mode and extent of binding between fish sperm DNA and the complexes were investigated using fluorescence spectroscopy and molecular docking. These results indicate the ability of the complexes to bind to DNA with different binding affinities. The binding of the Zn(II) complex with DNA is stronger than that of the corresponding Cu(II) analogue, which is expected due to the z* effect and geometry. The ability of these complexes to cleave pBR322 plasmid DNA was demonstrated using gel electrophoresis assay, showing that the complexes have effective DNA cleavage activity. In addition, the cytotoxic effects of these complexes were examined on HeLa cells (human cervix epithelia carcinoma cells) in vitro. The three complexes exhibit different cytotoxic effects and decent cancer cell inhibitory rate. This means that the structures and type of metal have a great influence on the activity of these novel complexes.

show abstract

“…Moreover, important application of polymerization reactions is in the quest for dental filling materials as a substitute for amalgams [4]. The carboxylate group display a variety of binding geometries, such as monodentate, chelating, bidentate bridging and monodentate bridging so in coordination chemistry as well as in the active sites of metalloenzymes [5][6][7][8][9]. It should be noted that the crystal structures of indole-3-propionic acid have been reported [10,11], but no single crystal X-ray diffraction analysis has been performed for its metal complexes, as yet.…”

Section: Introductionmentioning

confidence: 99%